| Literature DB >> 26490187 |
Ichiro Fukumoto1,2, Naoko Kikkawa2, Ryosuke Matsushita3, Mayuko Kato1, Akira Kurozumi1, Rika Nishikawa1, Yusuke Goto1, Keiichi Koshizuka1,2, Toyoyuki Hanazawa2, Hideki Enokida3, Masayuki Nakagawa3, Yoshitaka Okamoto2, Naohiko Seki1.
Abstract
In spite of considerable advances in multimodality therapy, including surgery, radiotherapy and chemotherapy, the overall survival rate for patients with head and neck squamous cell carcinoma (HNSCC) is very poor (only 15-45%). Understanding the molecular mechanisms of metastatic pathways underlying HNSCC using currently available genomic approaches might improve therapies for and prevention of the disease. Our previous studies showed that three tumor-suppressive microRNAs (miRNAs), miR-26a/b, miR-29a/b/c and miR-218, significantly inhibited cancer cell migration and invasion. Therefore, we hypothesized that these miRNAs-regulated target genes deeply contributed to cancer metastasis. These tumor-suppressive miRNAs directly regulate LOXL2 expression in HNSCC cells by using in silico analysis and luciferase reporter assays. Overexpressed LOXL2 was confirmed in HNSCC clinical specimens, and silencing of LOXL2 inhibited cancer cell migration and invasion in HNSCC cell lines. Our present data showed that tumor-suppressive miRNAs regulation of LOXL2 will provide new insights into the novel molecular mechanisms of HNSCC metastasis.Entities:
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Year: 2015 PMID： 26490187 DOI： 10.1038/jhg.2015.120
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172