Literature DB >> 2648995

Carboxypeptidase inhibitors from Ascaris suum: the primary structure.

G A Homandberg1, R D Litwiller, R J Peanasky.   

Abstract

The carboxypeptidase A inhibitor from Ascaris suum was isolated from aqueous extracts by affinity chromatography toward immobilized carboxypeptidase A. The amino acid sequence is DQVRKCLSDT10DCTNGEKCVQ20KNKICSTIVE30IQRCEKEHFT40IPCKSNNDCQ50VWAHEKICN K60LPWGL65 . The carboxypeptidase A inhibitor is not homologous with the chymotrypsin/elastase or trypsin inhibitors from Ascaris, but shows homology in a 9-residue internal sequence with the 37/39-residue carboxypeptidase inhibitors from tomato and potato. The carboxy-terminal 5 (4) residues in the three inhibitors are similar, suggesting a common mechanism of inhibition.

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Year:  1989        PMID： 2648995     DOI： 10.1016/0003-9861(89)90017-9

Source DB:  PubMed          Journal:  Arch Biochem Biophys        ISSN： 0003-9861            Impact factor:   4.013


  8 in total

Review 1.  Evolutionary families of peptidase inhibitors.

Authors:  Neil D Rawlings; Dominic P Tolle; Alan J Barrett
Journal:  Biochem J       Date:  2004-03-15       Impact factor: 3.857

2.  Tri-domain bifunctional inhibitor of metallocarboxypeptidases A and serine proteases isolated from marine annelid Sabellastarte magnifica.

Authors:  Maday Alonso-del-Rivero; Sebastian A Trejo; Mey L Reytor; Monica Rodriguez-de-la-Vega; Julieta Delfin; Joaquin Diaz; Yamile González-González; Francesc Canals; Maria Angeles Chavez; Francesc X Aviles
Journal:  J Biol Chem       Date:  2012-03-12       Impact factor: 5.157

Review 3.  High performance affinity chromatography and related separation methods for the analysis of biological and pharmaceutical agents.

Authors:  Chenhua Zhang; Elliott Rodriguez; Cong Bi; Xiwei Zheng; Doddavenkatana Suresh; Kyungah Suh; Zhao Li; Fawzi Elsebaei; David S Hage
Journal:  Analyst       Date:  2018-01-15       Impact factor: 4.616

4.  Mammalian metallopeptidase inhibition at the defense barrier of Ascaris parasite.

Authors:  Laura Sanglas; Francesc X Aviles; Robert Huber; F Xavier Gomis-Rüth; Joan L Arolas
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-28       Impact factor: 11.205

5.  Crystal structure and mechanism of human carboxypeptidase O: Insights into its specific activity for acidic residues.

Authors:  Maria C Garcia-Guerrero; Javier Garcia-Pardo; Esther Berenguer; Roberto Fernandez-Alvarez; Gifty B Barfi; Peter J Lyons; Francesc X Aviles; Robert Huber; Julia Lorenzo; David Reverter
Journal:  Proc Natl Acad Sci U S A       Date:  2018-04-10       Impact factor: 11.205

6.  Purification, cDNA cloning, functional expression, and characterization of a 26-kDa endogenous mammalian carboxypeptidase inhibitor.

Authors:  E Normant; M P Martres; J C Schwartz; C Gros
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-19       Impact factor: 11.205

7.  Plasticity in the Oxidative Folding Pathway of the High Affinity Nerita Versicolor Carboxypeptidase Inhibitor (NvCI).

Authors:  Sebastián A Esperante; Giovanni Covaleda; Sebastián A Trejo; Sílvia Bronsoms; Francesc X Aviles; Salvador Ventura
Journal:  Sci Rep       Date:  2017-07-14       Impact factor: 4.379

8.  Biochemical and MALDI-TOF Mass Spectrometric Characterization of a Novel Native and Recombinant Cystine Knot Miniprotein from Solanum tuberosum subsp. andigenum cv. Churqueña.

Authors:  Juliana Cotabarren; Mariana Edith Tellechea; Sebastián Martín Tanco; Julia Lorenzo; Javier Garcia-Pardo; Francesc Xavier Avilés; Walter David Obregón
Journal:  Int J Mol Sci       Date:  2018-02-28       Impact factor: 5.923
  8 in total

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