Literature DB >> 26488813

Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain.

Yangzom D Bhutia1, Vadivel Ganapathy2.   

Abstract

In this issue of Immunity, Haghikia and colleagues (2015) demonstrate that dietary fatty acids, by modulating gut microbes and their metabolism, regulate mucosal immune cells to impact systemic immunity. Using this mechanism, dietary and bacteria-derived medium-chain and long-chain fatty acids exacerbate, whereas short-chain fatty acids ameliorate, autoimmunity in the brain.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26488813      PMCID： PMC4930151          DOI： 10.1016/j.immuni.2015.09.014

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

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3.  Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine.

Authors:  Aiden Haghikia; Stefanie Jörg; Alexander Duscha; Johannes Berg; Arndt Manzel; Anne Waschbisch; Anna Hammer; De-Hyung Lee; Caroline May; Nicola Wilck; Andras Balogh; Annika I Ostermann; Nils Helge Schebb; Denis A Akkad; Diana A Grohme; Markus Kleinewietfeld; Stefan Kempa; Jan Thöne; Seray Demir; Dominik N Müller; Ralf Gold; Ralf A Linker
Journal:  Immunity       Date:  2015-10-20       Impact factor: 31.745

Review 4.  Diet, microbiota and autoimmune diseases.

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5.  Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.

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6.  Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions.

Authors:  Ashish Gurav; Sathish Sivaprakasam; Yangzom D Bhutia; Thomas Boettger; Nagendra Singh; Vadivel Ganapathy
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Review 7.  Peripheral education of the immune system by the colonic microbiota.

Authors:  Kristine A Kuhn; Thaddeus S Stappenbeck
Journal:  Semin Immunol       Date:  2013-10-26       Impact factor: 11.130

Review 8.  The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity.

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Review 9.  Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation.

Authors:  Chang H Kim; Jeongho Park; Myunghoo Kim
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  9 in total
  24 in total

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Authors:  Zinah Zamil Al-Ghezi; Philip Brandon Busbee; Hasan Alghetaa; Prakash S Nagarkatti; Mitzi Nagarkatti
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Review 2.  Role of Short Chain Fatty Acid Receptors in Intestinal Physiology and Pathophysiology.

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Journal:  Compr Physiol       Date:  2018-06-18       Impact factor: 9.090

3.  Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota.

Authors:  Francesca Cignarella; Claudia Cantoni; Laura Ghezzi; Amber Salter; Yair Dorsett; Lei Chen; Daniel Phillips; George M Weinstock; Luigi Fontana; Anne H Cross; Yanjiao Zhou; Laura Piccio
Journal:  Cell Metab       Date:  2018-06-05       Impact factor: 27.287

Review 4.  Targeting gut microbiota as a possible therapy for mastitis.

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Journal:  Eur J Clin Microbiol Infect Dis       Date:  2019-05-11       Impact factor: 3.267

Review 5.  The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes.

Authors:  Anna Winiarska-Mieczan; Ewa Tomaszewska; Janine Donaldson; Karolina Jachimowicz
Journal:  Nutrients       Date:  2022-06-16       Impact factor: 6.706

6.  Deuteration of the farnesyl terminal methyl groups of δ-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production.

Authors:  Xingui Liu; Zhengya Gao; Qiang Fu; Lin Song; Peiyi Zhang; Xuan Zhang; Howard Hendrickson; Peter A Crooks; Daohong Zhou; Guangrong Zheng
Journal:  Bioorg Med Chem       Date:  2020-04-08       Impact factor: 3.641

Review 7.  Microbiota metabolite short chain fatty acids, GPCR, and inflammatory bowel diseases.

Authors:  Mingming Sun; Wei Wu; Zhanju Liu; Yingzi Cong
Journal:  J Gastroenterol       Date:  2016-07-23       Impact factor: 7.527

Review 8.  SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

Authors:  Medha Priyadarshini; Barton Wicksteed; Gary E Schiltz; Annette Gilchrist; Brian T Layden
Journal:  Trends Endocrinol Metab       Date:  2016-04-15       Impact factor: 12.015

Review 9.  SLC transporters as a novel class of tumour suppressors: identity, function and molecular mechanisms.

Authors:  Yangzom D Bhutia; Ellappan Babu; Sabarish Ramachandran; Shengping Yang; Muthusamy Thangaraju; Vadivel Ganapathy
Journal:  Biochem J       Date:  2016-05-01       Impact factor: 3.857

10.  Gut Microbiome and Colon Cancer: Role of Bacterial Metabolites and Their Molecular Targets in the Host.

Authors:  Yangzom D Bhutia; Jiro Ogura; Sathish Sivaprakasam; Vadivel Ganapathy
Journal:  Curr Colorectal Cancer Rep       Date:  2017-02-22
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