Literature DB >> 26488015

The promise of lung master protocol for squamous cell carcinoma: one trial to rule them all, one trial to find them…?

Gavin Michael Wright1, Prudence Anne Russell1.   

Abstract

The recently initiated lung master protocol (Lung-MAP) trial provides hope that the successes of targeted molecular therapy in lung adenocarcinoma can be extended to squamous cell carcinoma (SCC). It also is a template for rapid translation of clinical research through regulatory approval to clinical practice. This is vital in cancers with multiple possible oncogenic genomic aberrations, for which clinical trials would be too costly and impractical to conduct for individual targets making up less than 10% of cases.

Entities:  

Keywords:  Biomarker; clinical trial; non-small cell lung cancer (NSCLC)

Year:  2015        PMID： 26488015      PMCID： PMC4583595          DOI： 10.3978/j.issn.2305-5839.2015.07.24

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  5 in total

Review 1.  Cyclin D as a therapeutic target in cancer.

Authors:  Elizabeth A Musgrove; C Elizabeth Caldon; Jane Barraclough; Andrew Stone; Robert L Sutherland
Journal:  Nat Rev Cancer       Date:  2011-07-07       Impact factor: 60.716

2.  Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400.

Authors:  Roy S Herbst; David R Gandara; Fred R Hirsch; Mary W Redman; Michael LeBlanc; Philip C Mack; Lawrence H Schwartz; Everett Vokes; Suresh S Ramalingam; Jeffrey D Bradley; Dana Sparks; Yang Zhou; Crystal Miwa; Vincent A Miller; Roman Yelensky; Yali Li; Jeff D Allen; Ellen V Sigal; David Wholley; Caroline C Sigman; Gideon M Blumenthal; Shakun Malik; Gary J Kelloff; Jeffrey S Abrams; Charles D Blanke; Vassiliki A Papadimitrakopoulou
Journal:  Clin Cancer Res       Date:  2015-02-13       Impact factor: 12.531

3.  Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

Authors:  Jonathan Weiss; Martin L Sos; Danila Seidel; Martin Peifer; Thomas Zander; Johannes M Heuckmann; Roland T Ullrich; Roopika Menon; Sebastian Maier; Alex Soltermann; Holger Moch; Patrick Wagener; Florian Fischer; Stefanie Heynck; Mirjam Koker; Jakob Schöttle; Frauke Leenders; Franziska Gabler; Ines Dabow; Silvia Querings; Lukas C Heukamp; Hyatt Balke-Want; Sascha Ansén; Daniel Rauh; Ingelore Baessmann; Janine Altmüller; Zoe Wainer; Matthew Conron; Gavin Wright; Prudence Russell; Ben Solomon; Elisabeth Brambilla; Christian Brambilla; Philippe Lorimier; Steinar Sollberg; Odd Terje Brustugun; Walburga Engel-Riedel; Corinna Ludwig; Iver Petersen; Jörg Sänger; Joachim Clement; Harry Groen; Wim Timens; Hannie Sietsma; Erik Thunnissen; Egbert Smit; Daniëlle Heideman; Federico Cappuzzo; Claudia Ligorio; Stefania Damiani; Michael Hallek; Rameen Beroukhim; William Pao; Bert Klebl; Matthias Baumann; Reinhard Buettner; Karen Ernestus; Erich Stoelben; Jürgen Wolf; Peter Nürnberg; Sven Perner; Roman K Thomas
Journal:  Sci Transl Med       Date:  2010-12-15       Impact factor: 17.956

4.  Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.

Authors:  Peter S Hammerman; Martin L Sos; Alex H Ramos; Chunxiao Xu; Amit Dutt; Wenjun Zhou; Lear E Brace; Brittany A Woods; Wenchu Lin; Jianming Zhang; Xianming Deng; Sang Min Lim; Stefanie Heynck; Martin Peifer; Jeffrey R Simard; Michael S Lawrence; Robert C Onofrio; Helga B Salvesen; Danila Seidel; Thomas Zander; Johannes M Heuckmann; Alex Soltermann; Holger Moch; Mirjam Koker; Frauke Leenders; Franziska Gabler; Silvia Querings; Sascha Ansén; Elisabeth Brambilla; Christian Brambilla; Philippe Lorimier; Odd Terje Brustugun; Aslaug Helland; Iver Petersen; Joachim H Clement; Harry Groen; Wim Timens; Hannie Sietsma; Erich Stoelben; Jürgen Wolf; David G Beer; Ming Sound Tsao; Megan Hanna; Charles Hatton; Michael J Eck; Pasi A Janne; Bruce E Johnson; Wendy Winckler; Heidi Greulich; Adam J Bass; Jeonghee Cho; Daniel Rauh; Nathanael S Gray; Kwok-Kin Wong; Eric B Haura; Roman K Thomas; Matthew Meyerson
Journal:  Cancer Discov       Date:  2011-06       Impact factor: 39.397

5.  Comprehensive genomic characterization of squamous cell lung cancers.

Authors: 
Journal:  Nature       Date:  2012-09-09       Impact factor: 49.962
  5 in total
  1 in total

1.  Analytical assessment of the novel Maglumi squamous cell carcinoma antigen (SCCA) immunoluminometric assay.

Authors:  Mariella Dipalo; Cecilia Gnocchi; Rosalia Aloe; Giuseppe Lippi
Journal:  Ann Transl Med       Date:  2015-12
  1 in total

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