Literature DB >> 26485016

Use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to detect carbapenemase production in Enterobacteriaceae by a rapid meropenem degradation assay.

Claudio Foschi1, Vincenzo Franza1, Matteo Conti2, Maria Vittoria Tamburini1, Greta Roncarati1, Miriam Cordovana1, Viktoria Smirnova1, Daniela Patrono2, Rita Mancini2, Maria Paola Landini1, Simone Ambretti1.   

Abstract

We evaluated the analytical performance of a liquid chromatography-tandem mass spectrometry assay to detect carbapenemase activity in a group of carbapenemase-producing Enterobacteriaceae by meropenem hydrolysis. This one-hour method showed a sensitivity of 94% and a specificity of 100%, representing a rapid and reliable option compared to conventional phenotypic assays.

Entities:  

Keywords:  Carbapenem resistance; Carbapenemase activity; Enterobacteriaceae; Liquid chromatography-tandem mass spectrometry; Meropenem hydrolysis

Mesh：

Substances：

Year:  2015        PMID： 26485016

Source DB:  PubMed          Journal:  New Microbiol        ISSN： 1121-7138            Impact factor:   2.479


  4 in total

1.  High-performance method to detection of Klebsiella pneumoniae Carbapenemase in Enterobacterales by LC-MS/MS.

Authors:  Otávio A Lovison; Renata B Rau; Daiana Lima-Morales; Evellyn K Almeida; Marina N Crispim; Fabiano Barreto; Afonso L Barth; Andreza F Martins
Journal:  Braz J Microbiol       Date:  2020-01-27       Impact factor: 2.476

2.  Rapid LC-MS/MS detection of different carbapenemase types in carbapenemase-producing Enterobacterales.

Authors:  Gen Li; Zhihan Ye; Nianzhen Chen; Wenyan Zhang; Yangqin Ye; Yuchao Wang; Fei Wu; Keli Wang; Lieying Fan
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2022-04-09       Impact factor: 3.267

Review 3.  One System for All: Is Mass Spectrometry a Future Alternative for Conventional Antibiotic Susceptibility Testing?

Authors:  Martin Welker; Alex van Belkum
Journal:  Front Microbiol       Date:  2019-11-26       Impact factor: 5.640

4.  Peptide Markers for Rapid Detection of KPC Carbapenemase by LC-MS/MS.

Authors:  Honghui Wang; Steven K Drake; Jung-Ho Youn; Avi Z Rosenberg; Yong Chen; Marjan Gucek; Anthony F Suffredini; John P Dekker
Journal:  Sci Rep       Date:  2017-05-31       Impact factor: 4.379
  4 in total

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