| Literature DB >> 26484837 |
L Heylen1,2, M Naesens1,2, I Jochmans3,2, D Monbaliu3,2, E Lerut4,5, K Claes1,2, S Heye6,5, P Verhamme7,8, W Coosemans3,2, B Bammens1,2, P Evenepoel1,2, B Meijers1,2, D Kuypers1,2, B Sprangers1,2, J Pirenne3,2.
Abstract
Whether warm ischemia during the time to complete the vascular anastomoses determines renal allograft function has not been investigated systematically. We investigated the effect of anastomosis time on allograft outcome in 669 first, single kidney transplantations from brain-dead donors. Anastomosis time independently increased the risk of delayed graft function (odds ratio per minute [OR] 1.05, 95% confidence interval [CI] 1.02-1.07, p < 0.001) and independently impaired allograft function after transplantation (p = 0.009, mixed-models repeated-measures analysis). In a subgroup of transplant recipients, protocol-specified biopsies at 3 months (n = 186), 1 year (n = 189), and 2 years (n = 153) were blindly reviewed. Prolonged anastomosis time independently increased the risk of interstitial fibrosis and tubular atrophy on these protocol-specified biopsies posttransplant (p < 0.001, generalized linear models). In conclusion, prolonged anastomosis time is not only detrimental for renal allograft outcome immediately after transplantation, also longer-term allograft function and histology are affected by the duration of this warm ischemia. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.Entities:
Keywords: DGF; allograft function; interstitial fibrosis; ischemia; kidney transplantation
Mesh：
Year: 2015 PMID： 26484837 DOI： 10.1111/ajt.13397
Source DB: PubMed Journal: Am J Transplant ISSN： 1600-6135 Impact factor: 8.086