Literature DB >> 26483576

Failure to thrive and life-threatening complications due to inherited selective cobalamin malabsorption effectively managed in a juvenile Australian shepherd dog.

Ashley J Gold1, Michael A Scott1, John C Fyfe1.   

Abstract

A juvenile Australian shepherd dog exhibited failure to grow, inappetence, weakness, nonregenerative anemia, neutropenia, and cobalamin deficiency. DNA testing confirmed homozygosity of an amnionless mutation (AMN c.3G > A). Clinical signs resolved with supportive care and parenteral cobalamin supplementation. Inherited selective intestinal cobalamin malabsorption requiring lifelong parenteral supplementation should be considered in Australian shepherds, giant schnauzers, border collies, and beagles that fail to thrive.

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Year:  2015        PMID： 26483576      PMCID： PMC4572816     

Source DB:  PubMed          Journal:  Can Vet J        ISSN： 0008-5286            Impact factor:   1.008


  19 in total

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Journal:  J Am Anim Hosp Assoc       Date:  1999 Sep-Oct       Impact factor: 1.023

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Journal:  Nat Genet       Date:  1999-03       Impact factor: 38.330

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Authors:  Qianchuan He; Mette Madsen; Adam Kilkenney; Brittany Gregory; Erik I Christensen; Henrik Vorum; Peter Højrup; Alejandro A Schäffer; Ewen F Kirkness; Stephan M Tanner; Albert de la Chapelle; Urs Giger; Søren K Moestrup; John C Fyfe
Journal:  Blood       Date:  2005-04-21       Impact factor: 22.113

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Authors:  Ruma Banerjee
Journal:  ACS Chem Biol       Date:  2006-04-25       Impact factor: 5.100

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Authors:  I A Battersby; U Giger; E J Hall
Journal:  J Small Anim Pract       Date:  2005-07       Impact factor: 1.522

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Journal:  Am J Physiol       Date:  1981-10
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  5 in total

1.  Prospective long-term evaluation of parenteral hydroxocobalamin supplementation in juvenile beagles with selective intestinal cobalamin malabsorption (Imerslund-Gräsbeck syndrome).

Authors:  Peter Hendrik Kook; C E Reusch; M Hersberger
Journal:  J Vet Intern Med       Date:  2018-03-23       Impact factor: 3.333

2.  Daily oral cyanocobalamin supplementation in Beagles with hereditary cobalamin malabsorption (Imerslund-Gräsbeck syndrome) maintains normal clinical and cellular cobalamin status.

Authors:  Peter H Kook; Martin Hersberger
Journal:  J Vet Intern Med       Date:  2018-12-15       Impact factor: 3.333

3.  Time course of serum cobalamin, folate, and total iron binding capacity concentrations in pregnant bitches and association with hematological variables and survival.

Authors:  Ran Nivy; Michal Mazaki-Tovi; Itamar Aroch; Smadar Tal
Journal:  J Vet Intern Med       Date:  2019-06-30       Impact factor: 3.333

Review 4.  Review of cobalamin status and disorders of cobalamin metabolism in dogs.

Authors:  Stefanie Kather; Niels Grützner; Peter H Kook; Franziska Dengler; Romy M Heilmann
Journal:  J Vet Intern Med       Date:  2019-11-23       Impact factor: 3.333

5.  A large deletion on CFA28 omitting ACSL5 gene is associated with intestinal lipid malabsorption in the Australian Kelpie dog breed.

Authors:  Mitchell J O'Brien; Niek J Beijerink; Mandy Sansom; Sarah W Thornton; Tracy Chew; Claire M Wade
Journal:  Sci Rep       Date:  2020-10-26       Impact factor: 4.379
  5 in total

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