| Literature DB >> 26483478 |
Xiao-Guang Chen1, Xuanting Jiang2, Jinbao Gu3, Meng Xu2, Yang Wu3, Yuhua Deng3, Chi Zhang2, Mariangela Bonizzoni4, Wannes Dermauw5, John Vontas6, Peter Armbruster7, Xin Huang7, Yulan Yang2, Hao Zhang3, Weiming He2, Hongjuan Peng3, Yongfeng Liu2, Kun Wu3, Jiahua Chen2, Manolis Lirakis8, Pantelis Topalis9, Thomas Van Leeuwen10, Andrew Brantley Hall11, Xiaofang Jiang11, Chevon Thorpe12, Rachel Lockridge Mueller13, Cheng Sun13, Robert Michael Waterhouse14, Guiyun Yan15, Zhijian Jake Tu11, Xiaodong Fang16, Anthony A James17.
Abstract
The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant population-based size variation. The complete genome sequence was determined for the Foshan strain, an established laboratory colony derived from wild mosquitoes from southeastern China, a region within the historical range of the origin of the species. The genome comprises 1,967 Mb, the largest mosquito genome sequenced to date, and its size results principally from an abundance of repetitive DNA classes. In addition, expansions of the numbers of members in gene families involved in insecticide-resistance mechanisms, diapause, sex determination, immunity, and olfaction also contribute to the larger size. Portions of integrated flavivirus-like genomes support a shared evolutionary history of association of these viruses with their vector. The large genome repertory may contribute to the adaptability and success of Ae. albopictus as an invasive species.Entities:
Keywords: diapause; flavivirus; insecticide resistance; mosquito genome; transposons
Mesh：
Year: 2015 PMID： 26483478 PMCID： PMC4640774 DOI： 10.1073/pnas.1516410112
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205