Kijin Kim1, Nayoung Ahn2, Jusik Park2, Jinho Koh2, Suryun Jung2, Sanghyun Kim2, Sangbok Moon2. 1. Department of Physical Education, College of Physical Education, Keimyung University, Daegu, Republic of Korea. Electronic address: kjk744@kmu.ac.kr. 2. Department of Physical Education, College of Physical Education, Keimyung University, Daegu, Republic of Korea.
Abstract
OBJECTIVE: This study analysed the risk factors associated with metabolic syndrome through the interaction between ACTN3 and ACE gene polymorphism in Korean children. METHODS: The subjects of the study consisted of elementary school students (n=788, age 10.10±0.07 yr). The anthropometric parameters, blood lipid profiles, and metabolic markers were compared among groups of the ACE I/D or the ACTN3 R577X polymorphisms. RESULTS: The subjects with the DD genotype showed significantly higher systolic blood pressure than the subjects with the II and ID genotype of the ACE gene polymorphism. XX genotype had significantly lower waist-hip ratio than those with RR genotype of the ACTN3 gene polymorphism. Also, the subjects with XX genotype exhibited significantly higher blood HDL cholesterol level than those with RR or RX genotype. The interaction of ACTN3 and ACE gene polymorphism in subjects having both ACE DD and ACTN3 RR genotypes demonstrated a significantly higher metabolic syndrome score than any other groups. CONCLUSION: The children having both ACTN3 RR or RX genotype and ACE DD genotype showed high systolic blood pressure and low blood HDL cholesterol level, which may be considered a high-risk in metabolic syndrome.
OBJECTIVE: This study analysed the risk factors associated with metabolic syndrome through the interaction between ACTN3 and ACE gene polymorphism in Korean children. METHODS: The subjects of the study consisted of elementary school students (n=788, age 10.10±0.07 yr). The anthropometric parameters, blood lipid profiles, and metabolic markers were compared among groups of the ACE I/D or the ACTN3R577X polymorphisms. RESULTS: The subjects with the DD genotype showed significantly higher systolic blood pressure than the subjects with the II and ID genotype of the ACE gene polymorphism. XX genotype had significantly lower waist-hip ratio than those with RR genotype of the ACTN3 gene polymorphism. Also, the subjects with XX genotype exhibited significantly higher blood HDL cholesterol level than those with RR or RX genotype. The interaction of ACTN3 and ACE gene polymorphism in subjects having both ACE DD and ACTN3 RR genotypes demonstrated a significantly higher metabolic syndrome score than any other groups. CONCLUSION: The children having both ACTN3 RR or RX genotype and ACE DD genotype showed high systolic blood pressure and low blood HDL cholesterol level, which may be considered a high-risk in metabolic syndrome.
Authors: Fleur C Garton; Peter J Houweling; Damjan Vukcevic; Lyra R Meehan; Fiona X Z Lee; Monkol Lek; Kelly N Roeszler; Marshall W Hogarth; Chrystal F Tiong; Diana Zannino; Nan Yang; Stephen Leslie; Paul Gregorevic; Stewart I Head; Jane T Seto; Kathryn N North Journal: Am J Hum Genet Date: 2018-04-26 Impact factor: 11.025
Authors: Samara Silva de Moura; Adália Táci Pereira Mendes; Francisco de Assis Dias Martins-Júnior; Nádia Lúcia Totou; Daniel Barbosa Coelho; Emerson Cruz de Oliveira; Daisy Motta-Santos; Robson Augusto Souza Dos Santos; Lenice Kappes Becker Journal: BMC Sports Sci Med Rehabil Date: 2021-05-06