Go Hirata1, Shigeru Aoki2, Kentaro Sakamaki3, Tsuneo Takahashi2, Fumiki Hirahara4, Hiroshi Ishikawa1. 1. a Department of Obstetrics , Kanagawa Children's Medical Center , Yokohama , Japan . 2. b Perinatal Center for Maternity and Neonate, Yokohama City University Medical Center , Yokohama , Japan . 3. c Department of Biostatistics , Yokohama City University , Yokohama , Japan , and. 4. d Department of Obstetrics and Gynecology , Yokohama City University Hospital , Yokohama , Japan.
Abstract
OBJECTIVE: To investigate clinical features of mirror syndrome. METHODS: We retrospectively reviewed 71 cases of fetal hydrops with or without mirror syndrome, and compared with respect to maternal age, the body mass index, the primipara rate, the gestational age at delivery, the timing of fetal hydrops onset, the severity of fetal edema, placental swelling, the laboratory data and the fetal mortality. The data are expressed as the medians. RESULTS: Mirror syndrome developed in 29% (10/35) of the cases with fetal hydrops. In mirror group, the onset time of fetal hydrops was significantly earlier (29 weeks versus 31 weeks, p = 0.011), and the severity of fetal hydrops (fetal edema/biparietal diameter) was significantly higher than non-mirror group (0.23 versus 0.16, p < 0.001). There was significantly higher serum human chorionic gonadotropin (hCG) (453,000 IU/L versus 80,000 IU/L, p < 0.001) and lower hemoglobin (8.9 g/dL versus 10.1 g/dL, p =0.002), hypoalbuminemia (2.3 mg/dL versus 2.7 mg/dL, p = 0.007), hyperuricemia (6.4 mg/dL versus 5.0 mg/dL, p = 0.043) in mirror group. CONCLUSION: Mirror syndrome is occurred frequently in early and severe fetal hydrops and cause hemodilution and elevation of serum hCG.
OBJECTIVE: To investigate clinical features of mirror syndrome. METHODS: We retrospectively reviewed 71 cases of fetal hydrops with or without mirror syndrome, and compared with respect to maternal age, the body mass index, the primipara rate, the gestational age at delivery, the timing of fetal hydrops onset, the severity of fetal edema, placental swelling, the laboratory data and the fetal mortality. The data are expressed as the medians. RESULTS:Mirror syndrome developed in 29% (10/35) of the cases with fetal hydrops. In mirror group, the onset time of fetal hydrops was significantly earlier (29 weeks versus 31 weeks, p = 0.011), and the severity of fetal hydrops (fetal edema/biparietal diameter) was significantly higher than non-mirror group (0.23 versus 0.16, p < 0.001). There was significantly higher serum humanchorionic gonadotropin (hCG) (453,000 IU/L versus 80,000 IU/L, p < 0.001) and lower hemoglobin (8.9 g/dL versus 10.1 g/dL, p =0.002), hypoalbuminemia (2.3 mg/dL versus 2.7 mg/dL, p = 0.007), hyperuricemia (6.4 mg/dL versus 5.0 mg/dL, p = 0.043) in mirror group. CONCLUSION:Mirror syndrome is occurred frequently in early and severe fetal hydrops and cause hemodilution and elevation of serum hCG.
Authors: Jesús Arnulfo Velásquez-Penagos; Ana María Flórez-Ríos; Edison Muñoz-Ortiz; Jairo Alfonso Gándara-Ricardo; Juan Pablo Flórez-Muñoz; Erika Holguín-González Journal: Rev Colomb Obstet Ginecol Date: 2021-09-30
Authors: Ivonne Alexandra Bedei; Alexander Graf; Karl-Philipp Gloning; Matthias Meyer-Wittkopf; Daria Willner; Martin Krapp; Sabine Hentze; Alexander Scharf; Jan Degenhardt; Kai-Sven Heling; Peter Kozlowski; Kathrin Trautmann; Kai Jahns; Anne Geipel; Ismail Tekesin; Michael Elsässer; Lucas Wilhelm; Ingo Gottschalk; Jan-Erik Baumüller; Cahit Birdir; Felix Zöllner; Aline Wolter; Johanna Schenk; Tascha Gehrke; Corinna Keil; Jimmy Espinosa; Roland Axt-Fliedner Journal: J Clin Med Date: 2022-08-05 Impact factor: 4.964