Li Tian1,2, Hui J Lu1, Lu Lin3, Yan Hu4. 1. School of Nursing, Fudan University, No. 305 Fenglin Road, Shanghai, 200032, China. 2. The First Affiliated Hospital of Soochow University, Suzhou, China. 3. School of Nursing, Soochow University, Suzhou, China. 4. School of Nursing, Fudan University, No. 305 Fenglin Road, Shanghai, 200032, China. huyan@fudan.edu.cn.
Abstract
BACKGROUND: Cancer-related fatigue (CRF) is the most commonly reported and most distressing symptom in cancer patients. Currently, there are no effective strategies for managing this condition. OBJECTIVE: The purpose of this study is to compare the effects of aerobic exercise on CRF with the standard of care. METHODS: A systematic search for randomized controlled trials (RCTs) was performed using the Cochrane Library, JBI Library, Embase, MEDLINE, Web of Science, China Biology Medicine (CBM), and China National Knowledge Infrastructure (CNKI). The risk of bias was critically evaluated, and data were independently extracted by two reviewers. All of the analyses were performed using Review Manager 5. RESULTS: A total of 26 qualified studies that included 2830 participants (aerobic exercise, 1426; control, 1404) were included in the meta-analysis. Cancer patients who completed adjuvant therapy in the aerobic exercise group reported reduced CRF levels relative to patients undergoing the standard of care. Aerobic exercise had a moderate effect on CRF for patients not currently undergoing anticancer treatment. Supervised aerobic exercise, exercise for 20–30 min/session, or exercise three times/week had a small effect on CRF. Exercise for 50 min/session or exercise two sessions/week had a significant effect on patient CRF, whereas 8 weeks of exercise had a moderate effect. CONCLUSIONS: Aerobic exercise is effective for the management of CRF, especially for patients who have completed adjuvant therapy. IMPLICATIONS FOR PRACTICE: Cancer patients can make more informed choices regarding their cancer-related fatigue management based on the best available evidence.
BACKGROUND:Cancer-related fatigue (CRF) is the most commonly reported and most distressing symptom in cancerpatients. Currently, there are no effective strategies for managing this condition. OBJECTIVE: The purpose of this study is to compare the effects of aerobic exercise on CRF with the standard of care. METHODS: A systematic search for randomized controlled trials (RCTs) was performed using the Cochrane Library, JBI Library, Embase, MEDLINE, Web of Science, China Biology Medicine (CBM), and China National Knowledge Infrastructure (CNKI). The risk of bias was critically evaluated, and data were independently extracted by two reviewers. All of the analyses were performed using Review Manager 5. RESULTS: A total of 26 qualified studies that included 2830 participants (aerobic exercise, 1426; control, 1404) were included in the meta-analysis. Cancerpatients who completed adjuvant therapy in the aerobic exercise group reported reduced CRF levels relative to patients undergoing the standard of care. Aerobic exercise had a moderate effect on CRF for patients not currently undergoing anticancer treatment. Supervised aerobic exercise, exercise for 20–30 min/session, or exercise three times/week had a small effect on CRF. Exercise for 50 min/session or exercise two sessions/week had a significant effect on patient CRF, whereas 8 weeks of exercise had a moderate effect. CONCLUSIONS: Aerobic exercise is effective for the management of CRF, especially for patients who have completed adjuvant therapy. IMPLICATIONS FOR PRACTICE: Cancerpatients can make more informed choices regarding their cancer-related fatigue management based on the best available evidence.
Authors: Bernardine M Pinto; Georita M Frierson; Carolyn Rabin; Joseph J Trunzo; Bess H Marcus Journal: J Clin Oncol Date: 2005-05-20 Impact factor: 44.544
Authors: Shiraz I Mishra; Roberta W Scherer; Claire Snyder; Paula M Geigle; Debra R Berlanstein; Ozlem Topaloglu Journal: Cochrane Database Syst Rev Date: 2012-08-15
Authors: Vicki S Conn; Adam R Hafdahl; Davina C Porock; Roxanne McDaniel; Paul J Nielsen Journal: Support Care Cancer Date: 2006-01-31 Impact factor: 3.603
Authors: Victoria Mock; Constantine Frangakis; Nancy E Davidson; Mary E Ropka; Mary Pickett; Barbara Poniatowski; Kerry J Stewart; Lane Cameron; Kristin Zawacki; Laura J Podewils; Gary Cohen; Ruth McCorkle Journal: Psychooncology Date: 2005-06 Impact factor: 3.894
Authors: K S Courneya; C M Friedenreich; H A Quinney; A L A Fields; L W Jones; A S Fairey Journal: Eur J Cancer Care (Engl) Date: 2003-12 Impact factor: 2.520
Authors: Andrea L Cheville; Lori Rhudy; Jeffrey R Basford; Joan M Griffin; Ann Marie Flores Journal: Arch Phys Med Rehabil Date: 2016-08-31 Impact factor: 3.966
Authors: Yen Le; Zan Gao; Scarlett Lin Gomez; Zachary Pope; Ruocheng Dong; Laura Allen; Mei-Wei Chang; Judy Huei-Yu Wang Journal: J Immigr Minor Health Date: 2019-02
Authors: Kelly M Kenzik; Wendy Demark-Wahnefried; Patricia A Ganz; Graham Colditz; Cheryl L Rock; Laura Q Rogers Journal: Ann Behav Med Date: 2018-11-12
Authors: Jonna K VAN Vulpen; Maike G Sweegers; Petra H M Peeters; Kerry S Courneya; Robert U Newton; Neil K Aaronson; Paul B Jacobsen; Daniel A Galvão; Mai J Chinapaw; Karen Steindorf; Melinda L Irwin; Martijn M Stuiver; Sandi Hayes; Kathleen A Griffith; Ilse Mesters; Hans Knoop; Martine M Goedendorp; Nanette Mutrie; Amanda J Daley; Alex McConnachie; Martin Bohus; Lene Thorsen; Karl-Heinz Schulz; Camille E Short; Erica L James; Ronald C Plotnikoff; Martina E Schmidt; Cornelia M Ulrich; Marc VAN Beurden; Hester S Oldenburg; Gabe S Sonke; Wim H VAN Harten; Kathryn H Schmitz; Kerri M Winters-Stone; Miranda J Velthuis; Dennis R Taaffe; Willem VAN Mechelen; Marie José Kersten; Frans Nollet; Jennifer Wenzel; Joachim Wiskemann; Irma M Verdonck-DE Leeuw; Johannes Brug; Anne M May; Laurien M Buffart Journal: Med Sci Sports Exerc Date: 2020-02