Literature DB >> 26481908

Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder.

Florian Bootsman1, Rachel M Brouwer2, Sanne M Kemner2, Hugo G Schnack2, Astrid C van der Schot3, Ronald Vonk4, Manon H J Hillegers2, Dorret I Boomsma5, Hilleke E Hulshoff Pol2, Willem A Nolen6, René S Kahn2, Neeltje E M van Haren2.   

Abstract

The influence of genes and environment on the association between bipolar disorder (BD) and volumes of subcortical brain regions involved in emotion processing has rarely been studied. Furthermore, as far as we know, longitudinal twin studies of subcortical brain volume change in BD have not been carried out at all. In this study, we focused on the genetic and environmental contributions to cross-sectional and longitudinal measures of subcortical brain volumes in BD. A total of 99 twins from monozygotic and dizygotic pairs concordant or discordant for BD and 129 twins from monozygotic and dizygotic healthy control pairs underwent magnetic resonance imaging at baseline. Longitudinal assessment was carried out in 48 twins from monozygotic and dizygotic patient pairs and 52 twins from monozygotic and dizygotic control pairs. Subcortical volume measures were obtained with Freesurfer software and analyzed with structural equation modeling software OpenMx. At baseline, BD was phenotypically and genetically associated with smaller volumes of the thalamus, putamen and nucleus accumbens. BD was not associated with subcortical brain volume change over time in any of the examined regions. Heritability of subcortical volumes at baseline was high, whereas subcortical volume change had low heritability. Genes contributing to BD showed overlap with those associated with smaller volumes of the thalamus, putamen and nucleus accumbens at baseline. Further evaluation of genetic contributions to abnormalities in subcortical brain regions assumed to be involved in emotion processing is recommended.
Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.

Entities:  

Keywords:  Bipolar disorder; Heritability; Longitudinal twin study; Magnetic resonance imaging; Subcortical brain volumes

Mesh：

Substances：

Year:  2015        PMID： 26481908     DOI： 10.1016/j.euroneuro.2015.09.023

Source DB:  PubMed          Journal:  Eur Neuropsychopharmacol        ISSN： 0924-977X            Impact factor:   4.600


  5 in total

1.  Neuroanatomic and Functional Neuroimaging Findings.

Authors:  Alexandre Paim Diaz; Isabelle E Bauer; Marsal Sanches; Jair C Soares
Journal:  Curr Top Behav Neurosci       Date:  2021

2.  Twin studies for the investigation of the relationships between genetic factors and brain abnormalities in bipolar disorder.

Authors:  L Squarcina; C Fagnani; M Bellani; C A Altamura; P Brambilla
Journal:  Epidemiol Psychiatr Sci       Date:  2016-09-19       Impact factor: 6.892

3.  Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.

Authors:  Rachel M Brouwer; Matthew S Panizzon; David C Glahn; Derrek P Hibar; Xue Hua; Neda Jahanshad; Lucija Abramovic; Greig I de Zubicaray; Carol E Franz; Narelle K Hansell; Ian B Hickie; Marinka M G Koenis; Nicholas G Martin; Karen A Mather; Katie L McMahon; Hugo G Schnack; Lachlan T Strike; Suzanne C Swagerman; Anbupalam Thalamuthu; Wei Wen; John H Gilmore; Nitin Gogtay; René S Kahn; Perminder S Sachdev; Margaret J Wright; Dorret I Boomsma; William S Kremen; Paul M Thompson; Hilleke E Hulshoff Pol
Journal:  Hum Brain Mapp       Date:  2017-06-05       Impact factor: 5.038

4.  Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group.

Authors:  D P Hibar; L T Westlye; N T Doan; N Jahanshad; J W Cheung; C R K Ching; A Versace; A C Bilderbeck; A Uhlmann; B Mwangi; B Krämer; B Overs; C B Hartberg; C Abé; D Dima; D Grotegerd; E Sprooten; E Bøen; E Jimenez; F M Howells; G Delvecchio; H Temmingh; J Starke; J R C Almeida; J M Goikolea; J Houenou; L M Beard; L Rauer; L Abramovic; M Bonnin; M F Ponteduro; M Keil; M M Rive; N Yao; N Yalin; P Najt; P G Rosa; R Redlich; S Trost; S Hagenaars; S C Fears; S Alonso-Lana; T G M van Erp; T Nickson; T M Chaim-Avancini; T B Meier; T Elvsåshagen; U K Haukvik; W H Lee; A H Schene; A J Lloyd; A H Young; A Nugent; A M Dale; A Pfennig; A M McIntosh; B Lafer; B T Baune; C J Ekman; C A Zarate; C E Bearden; C Henry; C Simhandl; C McDonald; C Bourne; D J Stein; D H Wolf; D M Cannon; D C Glahn; D J Veltman; E Pomarol-Clotet; E Vieta; E J Canales-Rodriguez; F G Nery; F L S Duran; G F Busatto; G Roberts; G D Pearlson; G M Goodwin; H Kugel; H C Whalley; H G Ruhe; J C Soares; J M Fullerton; J K Rybakowski; J Savitz; K T Chaim; M Fatjó-Vilas; M G Soeiro-de-Souza; M P Boks; M V Zanetti; M C G Otaduy; M S Schaufelberger; M Alda; M Ingvar; M L Phillips; M J Kempton; M Bauer; M Landén; N S Lawrence; N E M van Haren; N R Horn; N B Freimer; O Gruber; P R Schofield; P B Mitchell; R S Kahn; R Lenroot; R Machado-Vieira; R A Ophoff; S Sarró; S Frangou; T D Satterthwaite; T Hajek; U Dannlowski; U F Malt; V Arolt; W F Gattaz; W C Drevets; X Caseras; I Agartz; P M Thompson; O A Andreassen
Journal:  Mol Psychiatry       Date:  2017-05-02       Impact factor: 15.992

5.  Evidence for association between familial bipolar risk and ventral striatal volume.

Authors:  T M Lancaster
Journal:  J Affect Disord       Date:  2018-02-17       Impact factor: 4.839
  5 in total

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