Sibel Altintas1, Eline P M Cardinaels2, Mathijs O Versteylen3, Ivo A Joosen3, Milan Seifert3, Joachim E Wildberger4, Harry J Crijns1, Patricia J Nelemans5, Marja P Van Dieijen-Visser2, Alma M A Mingels6, Marco Das4, Bas L Kietselaer7. 1. Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. 2. Central Diagnostic Laboratory, Department of Clinical Chemistry, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. 3. Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. 4. Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Department of Radiology, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. 5. Department of Epidemiology, CAPHRI School for Public Health and Primary Care, Maastricht University Faculty of Health, Medicine and Life Sciences, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. 6. Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Central Diagnostic Laboratory, Department of Clinical Chemistry, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. 7. Department of Cardiology, Maastricht University Medical Center (MUMC+), P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Cardiovascular Research Institute, School for Cardiovascular Diseases, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands; Department of Radiology, MUMC+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, The Netherlands. Electronic address: b.kietselaer@mumc.nl.
Abstract
BACKGROUND: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. OBJECTIVE: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. METHODS: 81 consecutive stable chest pain patients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. RESULTS: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values ≤ .021). Non-calcified plaque volume showed no association with hs-cTnT and NT-proBNP (r hs-cTnT = .050; r NT-proBNP = .087; P value = .660 and P value = .442). The "Sum plaque score" showed the highest correlation compared to other plaque parameters (r hs-cTnT = .362; r NT-proBNP = .409; P value = .001 and P value ≤ .001). CONCLUSION: Our data suggest that coronary plaque morphology parameters, derived by dedicated software, are associated with serum hs-cTnT and NT-proBNP concentrations.
BACKGROUND: Unstable plaque characteristics on coronary CT angiography (CTA), serum high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal Pro-Brain Natriuretic Peptide (NT-proBNP) concentrations are associated with cardiovascular events. OBJECTIVE: To investigate the association between coronary CTA defined quantifiable plaque characteristics, hs-cTnT and NT-proBNP. METHODS: 81 consecutive stable chest painpatients with an intermediate-to-high risk were analyzed. Coronary CTA was performed using a 64-slice multidetector-row CT-scanner. Total coronary plaque volume, calcified volume, non-calcified volume, plaque burden, remodeling index (RI) and number of plaques were measured using dedicated software. A total plaque score ("Sum plaque score") incorporating total plaque volume, RI, plaque burden and number of plaques was defined. Hs-cTnT and NT-proBNP concentrations were measured in serum samples before coronary CTA. RESULTS: Univariate regression analysis demonstrated significant associations of hs-cTnT and NT-proBNP with total plaque volume (r hs-cTnT = .256; r NT-proBNP = .270), calcified volume (r hs-cTnT = .344; r NT-proBNP = .344), RI (r hs-cTnT = .335; r NT-proBNP = .342) and number of plaques (r hs-cTnT = .355; r NT-proBNP = .301) (all P values ≤ .021). Non-calcified plaque volume showed no association with hs-cTnT and NT-proBNP (r hs-cTnT = .050; r NT-proBNP = .087; P value = .660 and P value = .442). The "Sum plaque score" showed the highest correlation compared to other plaque parameters (r hs-cTnT = .362; r NT-proBNP = .409; P value = .001 and P value ≤ .001). CONCLUSION: Our data suggest that coronary plaque morphology parameters, derived by dedicated software, are associated with serum hs-cTnT and NT-proBNP concentrations.
Authors: Kathleen V Fitch; Christopher DeFilippi; Robert Christenson; Suman Srinivasa; Hang Lee; Janet Lo; Michael T Lu; Kimberly Wong; Eva Petrow; Laura Sanchez; Sara E Looby; Udo Hoffmann; Markella Zanni; Steven K Grinspoon Journal: AIDS Date: 2016-09-10 Impact factor: 4.177
Authors: Jonas Rusnak; Michael Behnes; Nadine Reckord; Ursula Hoffmann; Michèle Natale; Julia Hoffmann; Kathrin Weidner; Siegfried Lang; Agnibh Mukherji; Mathieu Kruska; Thomas Henzler; Stefan O Schoenberg; Martin Borggrefe; Thomas Bertsch; Ibrahim Akin Journal: Dis Markers Date: 2017-07-18 Impact factor: 3.434