Moisés Rodríguez-Mañero1, María Teresa Barrio-López2, Emad Abu Assi3, Víctor Expósito-García4, Vicente Bertomeu-González5, Juan Miguel Sánchez-Gómez6, Luis González-Torres7, Ignacio García-Bolao8, Larraitz Gaztañaga9, Pilar Cabanas-Grandío10, José Antonio Iglesias-Bravo11, Álvaro Arce-León12, Ana Andrés la Huerta13, Juan Fernández-Armenta14, Rafael Peinado15, Miguel Angel Arias16, Ernesto Díaz-Infante7. 1. Unidad de Arritmias, Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. Electronic address: moirmanero@gmail.com. 2. Unidad de Arritmias, Servicio de Cardiología, Hospital Virgen de las Nieves, Granada, Spain. 3. Unidad de Arritmias, Servicio de Cardiología, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain. 4. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. 5. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario de San Juan, Sant Joan d'Alacant, Alicante, Spain. 6. Unidad de Arritmias, Servicio de Cardiología, Hospital Clínico Universitario de Valencia, Valencia, Spain. 7. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen Macarena, Seville, Spain. 8. Unidad de Arritmias, Servicio de Cardiología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain. 9. Unidad de Arritmias, Servicio de Cardiología, Hospital de Basurto, Bilbao, Vizcaya, Spain. 10. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario de Vigo, Vigo, Pontevedra, Spain. 11. Unidad de Arritmias, Servicio de Cardiología, Hospital Fundación Jiménez Díaz, Madrid, Spain. 12. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Seville, Spain. 13. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 14. Unidad de Arritmias, Servicio de Cardiología, Hospital Puerta del Mar, Cádiz, Spain. 15. Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario La Paz, Madrid, Spain. 16. Unidad de Arritmias, Servicio de Cardiología, Hospital Virgen de la Salud, Toledo, Spain.
Abstract
INTRODUCTION AND OBJECTIVES: Few data exist on the outcomes of valvular cardiomyopathy patients referred for defibrillator implantation for primary prevention. The aim of the present study was to describe the outcomes of this cardiomyopathy subgroup. METHODS: This multicenter retrospective study included consecutive patients referred for defibrillator implantation to 15 Spanish centers in 2010 and 2011, and to 3 centers after 1 January 2008. RESULTS: Of 1174 patients, 73 (6.2%) had valvular cardiomyopathy. These patients had worse functional class, wider QRS, and a history of atrial fibrillation vs patients with ischemic (n=659; 56.1%) or dilated (n=442; 37.6%) cardiomyopathy. During a follow-up of 38.1 ± 21.3 months, 197 patients (16.7%) died, without significant differences among the groups (19.2% in the valvular cardiomyopathy group, 15.8% in the ischemic cardiomyopathy group, and 17.9% in the dilated cardiomyopathy group; P=.2); 136 died of cardiovascular causes (11.6%), without significant differences among the groups (12.3%, 10.5%, and 13.1%, respectively; P=.1). Although there were no differences in the proportion of appropriate defibrillator interventions (13.7%, 17.9%, and 18.8%; P=.4), there was a difference in inappropriate interventions (8.2%, 7.1%, and 12.0%, respectively; P=.03). CONCLUSIONS: All-cause and cardiovascular mortality in patients with valvular cardiomyopathy were similar to those in other patients referred for defibrillator implantation. They also had similar rates of appropriate interventions. These data suggest that defibrillator implantation in this patient group confers a similar benefit to that obtained by patients with ischemic or dilated cardiomyopathy.
INTRODUCTION AND OBJECTIVES: Few data exist on the outcomes of valvular cardiomyopathypatients referred for defibrillator implantation for primary prevention. The aim of the present study was to describe the outcomes of this cardiomyopathy subgroup. METHODS: This multicenter retrospective study included consecutive patients referred for defibrillator implantation to 15 Spanish centers in 2010 and 2011, and to 3 centers after 1 January 2008. RESULTS: Of 1174 patients, 73 (6.2%) had valvular cardiomyopathy. These patients had worse functional class, wider QRS, and a history of atrial fibrillation vs patients with ischemic (n=659; 56.1%) or dilated (n=442; 37.6%) cardiomyopathy. During a follow-up of 38.1 ± 21.3 months, 197 patients (16.7%) died, without significant differences among the groups (19.2% in the valvular cardiomyopathy group, 15.8% in the ischemic cardiomyopathy group, and 17.9% in the dilated cardiomyopathy group; P=.2); 136 died of cardiovascular causes (11.6%), without significant differences among the groups (12.3%, 10.5%, and 13.1%, respectively; P=.1). Although there were no differences in the proportion of appropriate defibrillator interventions (13.7%, 17.9%, and 18.8%; P=.4), there was a difference in inappropriate interventions (8.2%, 7.1%, and 12.0%, respectively; P=.03). CONCLUSIONS: All-cause and cardiovascular mortality in patients with valvular cardiomyopathy were similar to those in other patients referred for defibrillator implantation. They also had similar rates of appropriate interventions. These data suggest that defibrillator implantation in this patient group confers a similar benefit to that obtained by patients with ischemic or dilated cardiomyopathy.
Authors: Leonard Bergau; Tobias Tichelbäcker; Barbora Kessel; Lars Lüthje; Thomas H Fischer; Tim Friede; Markus Zabel Journal: PLoS One Date: 2017-10-17 Impact factor: 3.240
Authors: Sem Briongos-Figuero; Arcadio García-Alberola; Jerónimo Rubio; José María Segura; Aníbal Rodríguez; Rafael Peinado; Javier Alzueta; José B Martínez-Ferrer; Xavier Viñolas; Joaquín Fernández de la Concha; Ignasi Anguera; María Martín; Laia Cerdá; Luisa Pérez Journal: J Am Heart Assoc Date: 2020-12-25 Impact factor: 5.501
Authors: David Conen; Barbora Arendacká; Christian Röver; Leonard Bergau; Pascal Munoz; Sofieke Wijers; Christian Sticherling; Markus Zabel; Tim Friede Journal: PLoS One Date: 2016-09-12 Impact factor: 3.240