| Literature DB >> 2647944 |
Y Asano1, T Yoshikawa, S Suga, T Yazaki, T Hata, T Nagai, Y Kajita, T Ozaki, S Yoshida.
Abstract
Mononuclear cell-associated viremia caused by human herpesvirus type 6 was detected in 39 (66%) of 59 blood samples from 38 children with exanthem subitum between day 0 and day 7 of the disease. The rate of virus isolation from mononuclear cells was 100% (26/26) on days 0 to 2 (just before appearance of skin rash), 82% (9/11) on day 3, 20% (2/10) on day 4, 7% (2/12) on days 5 to 7, and 0% (0/37) on day 8 and thereafter. The cell-free virus was detected in blood in 10 (21%) of 47 blood samples during the same period. The antibody activity to the virus, evaluated by a newly developed neutralization assay, was first detected on day 3 of the disease with a positive rate of 18% (2/11). It became 60% (6/10) on day 4, 75% (9/12) on days 5 to 7, and 100% on day 8 and thereafter. Thus the disappearance of the virus from blood was associated with the induction of specific immunity to the virus.Entities:
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Year: 1989 PMID： 2647944 DOI： 10.1016/s0022-3476(89)80689-4
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406