Y K Kiros1, T Teklu2, F Desalegn3, M Tesfay4, E Klinkenberg5, A Mulugeta1. 1. Mekelle University, Mekelle, Ethiopia. 2. Tigray Regional Health Bureau, Mekelle, Ethiopia. 3. Mekelle Hospital, Mekelle, Ethiopia. 4. Tigray Regional Laboratory, Mekelle, Ethiopia. 5. KNCV Tuberculosis Foundation, The Hague, The Netherlands ; Department of Global Health, Academic Medical Centre, University of Amsterdam, Amsterdam Institute for Global Health and Development, Amsterdam, The Netherlands.
Abstract
SETTING: Tuberculosis (TB) patients in Mekelle Zone, Tigray Region, in Ethiopia. OBJECTIVE: To investigate adherence to anti-tuberculosis treatment. DESIGN: A cross-sectional study in health facilities providing anti-tuberculosis treatment was conducted. Adherence was measured in three ways: through self-reported missed doses, by visual analogue scale whereby patients rate their own adherence and by record review. A patient was considered to be adherent if 90% or more of the prescribed medication was taken. RESULT: Of 278 TB patients included, 101 were in the intensive and 177 in the continuation phase. Respectively 67 (24.1%), 130 (46.8%) and 80 (28.8%) patients had smear-positive, smear-negative and extra-pulmonary TB. Self-report of missed doses and record review indicated adherence of respectively 273 (97.3%) and 271 (97.5%) patients. By visual analogue scale, 250 (91.6%) patients rated themselves as adherent. History of drug side effects (aOR 0.25, 95%CI 0.08-0.77) and knowledge about TB prevention (aOR 0.19, 95%CI 0.05-0.8) were independently associated with being adherent in this setting. CONCLUSION: Adherence to anti-tuberculosis treatment was high in our study. Adherence support should be given to the poor, the elderly, patients co-infected with the human immunodeficiency virus, alcohol abusers and smokers. Health education on TB prevention should be given to all TB patients regularly.
SETTING:Tuberculosis (TB) patients in Mekelle Zone, Tigray Region, in Ethiopia. OBJECTIVE: To investigate adherence to anti-tuberculosis treatment. DESIGN: A cross-sectional study in health facilities providing anti-tuberculosis treatment was conducted. Adherence was measured in three ways: through self-reported missed doses, by visual analogue scale whereby patients rate their own adherence and by record review. A patient was considered to be adherent if 90% or more of the prescribed medication was taken. RESULT: Of 278 TB patients included, 101 were in the intensive and 177 in the continuation phase. Respectively 67 (24.1%), 130 (46.8%) and 80 (28.8%) patients had smear-positive, smear-negative and extra-pulmonary TB. Self-report of missed doses and record review indicated adherence of respectively 273 (97.3%) and 271 (97.5%) patients. By visual analogue scale, 250 (91.6%) patients rated themselves as adherent. History of drug side effects (aOR 0.25, 95%CI 0.08-0.77) and knowledge about TB prevention (aOR 0.19, 95%CI 0.05-0.8) were independently associated with being adherent in this setting. CONCLUSION: Adherence to anti-tuberculosis treatment was high in our study. Adherence support should be given to the poor, the elderly, patients co-infected with the human immunodeficiency virus, alcohol abusers and smokers. Health education on TB prevention should be given to all TB patients regularly.
Authors: Monica G Amuha; Paul Kutyabami; Freddy E Kitutu; Richard Odoi-Adome; Joan N Kalyango Journal: Afr Health Sci Date: 2009-08-01 Impact factor: 0.927
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