Literature DB >> 26477700

Restoring calcium homeostasis to treat Alzheimer's disease: a future perspective.

Elena Popugaeva1, Olga L Vlasova1, Ilya Bezprozvanny1,2.   

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder that primarily compromises memory formation and storage. Several hypotheses regarding the pathogenesis of AD have been proposed; however, no cure is available to date. Here we describe the calcium hypothesis of AD, which is gaining popularity. We present data supporting this hypothesis and focus on a recently discovered calcium-signaling pathway that is dysregulated in AD and propose targets for the development of disease-modifying therapies.

Entities:  

Keywords:  Alzheimer disease; Ca2+ signaling; mushroom spine; neuronal store-operated Ca2+ channels; synapse

Mesh：

Year:  2015        PMID： 26477700      PMCID： PMC5558533          DOI： 10.2217/nmt.15.36

Source DB:  PubMed          Journal:  Neurodegener Dis Manag        ISSN： 1758-2024


  26 in total

1.  Presenilin-mediated modulation of capacitative calcium entry.

Authors:  A S Yoo; I Cheng; S Chung; T Z Grenfell; H Lee; E Pack-Chung; M Handler; J Shen; W Xia; G Tesco; A J Saunders; K Ding; M P Frosch; R E Tanzi; T W Kim
Journal:  Neuron       Date:  2000-09       Impact factor: 17.173

2.  Calcineurin links Ca2+ dysregulation with brain aging.

Authors:  T C Foster; K M Sharrow; J R Masse; C M Norris; A Kumar
Journal:  J Neurosci       Date:  2001-06-01       Impact factor: 6.167

3.  Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.

Authors:  Grace E Stutzmann; Ian Smith; Antonella Caccamo; Salvatore Oddo; Frank M Laferla; Ian Parker
Journal:  J Neurosci       Date:  2006-05-10       Impact factor: 6.167

4.  A phase 3 trial of semagacestat for treatment of Alzheimer's disease.

Authors:  Rachelle S Doody; Rema Raman; Martin Farlow; Takeshi Iwatsubo; Bruno Vellas; Steven Joffe; Karl Kieburtz; Feng He; Xiaoying Sun; Ronald G Thomas; Paul S Aisen; Eric Siemers; Gopalan Sethuraman; Richard Mohs
Journal:  N Engl J Med       Date:  2013-07-25       Impact factor: 91.245

Review 5.  Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease.

Authors:  Bart De Strooper
Journal:  EMBO Rep       Date:  2007-02       Impact factor: 8.807

6.  Lessons from a failed γ-secretase Alzheimer trial.

Authors:  Bart De Strooper
Journal:  Cell       Date:  2014-11-06       Impact factor: 41.582

Review 7.  Presenilin transgenic mice as models of Alzheimer's disease.

Authors:  Gregory A Elder; Miguel A Gama Sosa; Rita De Gasperi; Dara L Dickstein; Patrick R Hof
Journal:  Brain Struct Funct       Date:  2009-11-18       Impact factor: 3.270

8.  The mechanism of γ-Secretase dysfunction in familial Alzheimer disease.

Authors:  Lucía Chávez-Gutiérrez; Leen Bammens; Iryna Benilova; Annelies Vandersteen; Manasi Benurwar; Marianne Borgers; Sam Lismont; Lujia Zhou; Simon Van Cleynenbreugel; Hermann Esselmann; Jens Wiltfang; Lutgarde Serneels; Eric Karran; Harrie Gijsen; Joost Schymkowitz; Frederic Rousseau; Kerensa Broersen; Bart De Strooper
Journal:  EMBO J       Date:  2012-04-13       Impact factor: 11.598

9.  SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.

Authors:  Kim N Green; Angelo Demuro; Yama Akbari; Brian D Hitt; Ian F Smith; Ian Parker; Frank M LaFerla
Journal:  J Cell Biol       Date:  2008-06-30       Impact factor: 10.539

10.  STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.

Authors:  Elena Popugaeva; Ekaterina Pchitskaya; Anastasiya Speshilova; Sergey Alexandrov; Hua Zhang; Olga Vlasova; Ilya Bezprozvanny
Journal:  Mol Neurodegener       Date:  2015-08-15       Impact factor: 14.195
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  8 in total

1.  Xanthoceraside modulates NR2B-containing NMDA receptors at synapses and rescues learning-memory deficits in APP/PS1 transgenic mice.

Authors:  Lin Zhu; Lei Yang; Xuemei Zhao; Danyang Liu; Xiaoli Guo; Peng Liu; Tianyan Chi; Xuefei Ji; Libo Zou
Journal:  Psychopharmacology (Berl)       Date:  2017-11-09       Impact factor: 4.530

2.  Reversal of Calcium Dysregulation as Potential Approach for Treating Alzheimer's Disease.

Authors:  Elena Popugaeva; Daria Chernyuk; Ilya Bezprozvanny
Journal:  Curr Alzheimer Res       Date:  2020       Impact factor: 3.498

3.  Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes.

Authors:  Jea Kwon; Heeyoung An; Moonsun Sa; Joungha Won; Jeong Im Shin; C Justin Lee
Journal:  Exp Neurobiol       Date:  2017-02-09       Impact factor: 3.261

Review 4.  Intraluminal Farnesol and Farnesal in the Mealworm's Alimentary Canal: An Unusual Storage Site Uncovering Hidden Eukaryote Ca2+-Homeostasis-Dependent "Golgicrine" Activities.

Authors:  Arnold De Loof; Liliane Schoofs
Journal:  Front Endocrinol (Lausanne)       Date:  2019-12-19       Impact factor: 5.555

Review 5.  Store-Operated Calcium Channels in Physiological and Pathological States of the Nervous System.

Authors:  Isis Zhang; Huijuan Hu
Journal:  Front Cell Neurosci       Date:  2020-11-26       Impact factor: 5.505

Review 6.  The Role of NLRP3 Inflammasome in Alzheimer's Disease and Potential Therapeutic Targets.

Authors:  Tao Liang; Yang Zhang; Suyuan Wu; Qingjie Chen; Lin Wang
Journal:  Front Pharmacol       Date:  2022-02-16       Impact factor: 5.810

Review 7.  Computer-Based Drug Design of Positive Modulators of Store-Operated Calcium Channels to Prevent Synaptic Dysfunction in Alzheimer's Disease.

Authors:  Lernik Hunanyan; Viktor Ghamaryan; Ani Makichyan; Elena Popugaeva
Journal:  Int J Mol Sci       Date:  2021-12-19       Impact factor: 5.923

8.  Analysis of Shared Genetic Regulatory Networks for Alzheimer's Disease and Epilepsy.

Authors:  Xiao-Dan Wang; Shuai Liu; Hui Lu; Yalin Guan; Hao Wu; Yong Ji
Journal:  Biomed Res Int       Date:  2021-10-14       Impact factor: 3.411
  8 in total

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