Dushyant Kumar1,2, Susanne Siemonsen1,2, Christoph Heesen2,3, Jens Fiehler1, Jan Sedlacik1. 1. Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 2. Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. 3. Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Abstract
PURPOSE: To improve the quantification accuracy of transverse relaxometry by accounting for B1 -error, after minimizing slice profile imperfections. MATERIALS AND METHODS: The slice profile of refocusing pulses was optimized by setting refocusing slice thicknesses three times that of the excitation pulse. The first step of data processing combined the L-curve approach with the linearized version of the extended phase graph model to jointly estimate the temporal regularization constant map and the flip angle error (FAE)-map. The second step improved the noise robustness of the reconstruction by imposing a spatial smoothness constraint on T2 -distributions. The proposed method (spatial-regularization-with-FAE-correction) was evaluated against methods without FAE-correction (conventional-regularization-without-FAE-correction, spatial-regularization-without-FAE-correction) and conventional-regularization-with-FAE-correction using relevant statistics (simulated data: mean square myelin reconstruction error [MSMRE] and averaged-symmetric-Kullbeck-Leibler score [SKL] between returned distributions and ground truths; experimental data: median of mean square error [MMSE] of fitting across entire data-set and coefficient of variation [COV] in white-matter [WM] regions of interest [ROIs]). RESULTS: In simulation, our method resulted in reduced MSMRE (at signal-to-noise ratio [SNR] = 200: MSMRESpatial-regularization-without-FAEC = 0.057; MSMRESpatial-regularization-with-FAEC = 0.0107) and reduced SKL scores (at SNR = 200: SKLSpatial-regularization-without-FAEC = 0.061; SKLSpatial-regularization-with-FAEC = 0.0143). In human volunteers, our method yielded a reduced MSE of fitting (MMSESpatial-regularization-without-FAEC = (2.26 ± 0.60) × 10(-3) ; MMSESpatial-regularization-with-FAEC = (1.57 ± 0.44) × 10(-4) )and also resulted in reduced COV (COVSpatial-regularization-without-FAEC = 0.08-0.19; COVSpatial-regularization-with-FAEC = 0.09-0.12). In a water-phantom, a good correlation between the absolute value of measured B1 -map and FAE-map was found (regression analysis: slope = 1.04; R(2) = 0.66). CONCLUSION: The proposed method resulted in more accurate and noise robust myelin water fraction maps with improved depiction of subcortical WM structures.
PURPOSE: To improve the quantification accuracy of transverse relaxometry by accounting for B1 -error, after minimizing slice profile imperfections. MATERIALS AND METHODS: The slice profile of refocusing pulses was optimized by setting refocusing slice thicknesses three times that of the excitation pulse. The first step of data processing combined the L-curve approach with the linearized version of the extended phase graph model to jointly estimate the temporal regularization constant map and the flip angle error (FAE)-map. The second step improved the noise robustness of the reconstruction by imposing a spatial smoothness constraint on T2 -distributions. The proposed method (spatial-regularization-with-FAE-correction) was evaluated against methods without FAE-correction (conventional-regularization-without-FAE-correction, spatial-regularization-without-FAE-correction) and conventional-regularization-with-FAE-correction using relevant statistics (simulated data: mean square myelin reconstruction error [MSMRE] and averaged-symmetric-Kullbeck-Leibler score [SKL] between returned distributions and ground truths; experimental data: median of mean square error [MMSE] of fitting across entire data-set and coefficient of variation [COV] in white-matter [WM] regions of interest [ROIs]). RESULTS: In simulation, our method resulted in reduced MSMRE (at signal-to-noise ratio [SNR] = 200: MSMRESpatial-regularization-without-FAEC = 0.057; MSMRESpatial-regularization-with-FAEC = 0.0107) and reduced SKL scores (at SNR = 200: SKLSpatial-regularization-without-FAEC = 0.061; SKLSpatial-regularization-with-FAEC = 0.0143). In human volunteers, our method yielded a reduced MSE of fitting (MMSESpatial-regularization-without-FAEC = (2.26 ± 0.60) × 10(-3) ; MMSESpatial-regularization-with-FAEC = (1.57 ± 0.44) × 10(-4) )and also resulted in reduced COV (COVSpatial-regularization-without-FAEC = 0.08-0.19; COVSpatial-regularization-with-FAEC = 0.09-0.12). In a water-phantom, a good correlation between the absolute value of measured B1 -map and FAE-map was found (regression analysis: slope = 1.04; R(2) = 0.66). CONCLUSION: The proposed method resulted in more accurate and noise robust myelin water fraction maps with improved depiction of subcortical WM structures.
Authors: Mustapha Bouhrara; David A Reiter; Michael C Maring; Jean-Marie Bonny; Richard G Spencer Journal: J Neuroimaging Date: 2018-07-12 Impact factor: 2.486
Authors: Gerhard S Drenthen; Walter H Backes; Albert P Aldenkamp; Giel J Op 't Veld; Jacobus F A Jansen Journal: Magn Reson Med Date: 2018-11-16 Impact factor: 4.668