Daan Nevens1, Sarah Deschuymer1, Johannes A Langendijk2, Jean-François Daisne3, Fréderic Duprez4, Wilfried De Neve4, Sandra Nuyts5. 1. KU Leuven - University of Leuven, University Hospitals Leuven, Department of Radiation Oncology, Belgium. 2. Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands. 3. Department of Radiation Oncology, Clinique et Maternité Sainte-Elisabeth, Namur, Belgium. 4. Department of Radiotherapy, Ghent University Hospital, Belgium. 5. KU Leuven - University of Leuven, University Hospitals Leuven, Department of Radiation Oncology, Belgium. Electronic address: Sandra.nuyts@uzleuven.be.
Abstract
BACKGROUND AND PURPOSE: A risk model, the total dysphagia risk score (TDRS), was developed to predict which patients are most at risk to develop grade ⩾2 dysphagia at 6 months following radiotherapy (RT) for head and neck cancer. The purpose of this study was to validate this model at 6 months and to investigate the power at earlier and later time-points. A second aim was to see if this model can be used in a partially accelerated RT regimen. MATERIALS AND METHODS: 164 patients from 3 different centres treated with RT between 2008 and 2014 were included in the current study. Both physician-scored dysphagia and QoL data were prospectively obtained. The TDRS of all patients was correlated with the physician-scored dysphagia and the QoL data. To validate this prediction model, we tested the validity in terms of calibration and discrimination. RESULTS: Partial acceleration had no influence on the TDRS. Regarding physician-scored dysphagia, there was a significant correlation with dysphagia grade ⩾2 at 1, 3, 6 and 9 months. The area-under-the-curve at 1 month was 0.85; at 3 months 0.80; at 6 months 0.85; at 9 months 0.86 and 0.79 at 12 months. Regarding QoL, TDRS correlates with PEG-tube usage at 6 and 12 months. CONCLUSION: We found significant correlations between TDRS and dysphagia grade ⩾2 and PEG-tube usage.
BACKGROUND AND PURPOSE: A risk model, the total dysphagia risk score (TDRS), was developed to predict which patients are most at risk to develop grade ⩾2 dysphagia at 6 months following radiotherapy (RT) for head and neck cancer. The purpose of this study was to validate this model at 6 months and to investigate the power at earlier and later time-points. A second aim was to see if this model can be used in a partially accelerated RT regimen. MATERIALS AND METHODS: 164 patients from 3 different centres treated with RT between 2008 and 2014 were included in the current study. Both physician-scored dysphagia and QoL data were prospectively obtained. The TDRS of all patients was correlated with the physician-scored dysphagia and the QoL data. To validate this prediction model, we tested the validity in terms of calibration and discrimination. RESULTS: Partial acceleration had no influence on the TDRS. Regarding physician-scored dysphagia, there was a significant correlation with dysphagia grade ⩾2 at 1, 3, 6 and 9 months. The area-under-the-curve at 1 month was 0.85; at 3 months 0.80; at 6 months 0.85; at 9 months 0.86 and 0.79 at 12 months. Regarding QoL, TDRS correlates with PEG-tube usage at 6 and 12 months. CONCLUSION: We found significant correlations between TDRS and dysphagia grade ⩾2 and PEG-tube usage.
Authors: Daan Nevens; Ann Goeleven; Fréderic Duprez; R Braeken; E Decabooter; M De Smet; L Lutters; Eddy Dejaeger; Wilfried De Neve; Sandra Nuyts Journal: Br J Radiol Date: 2018-01-02 Impact factor: 3.039