Literature DB >> 26476576

Flipping a Lipid-Linked Oligosaccharide? You Must Whip It!

Mark A Lehrman1.   

Abstract

The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  dolichol; flippase; lipid-linked oligosaccharide; polyisoprenol; undecaprenol

Mesh：

Substances：

Year:  2015        PMID： 26476576      PMCID： PMC4661117          DOI： 10.1016/j.tibs.2015.10.001

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  8 in total

1.  Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.

Authors:  Jonne Helenius; Davis T W Ng; Cristina L Marolda; Peter Walter; Miguel A Valvano; Markus Aebi
Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

Review 2.  The ins(ide) and out(side) of dolichyl phosphate biosynthesis and recycling in the endoplasmic reticulum.

Authors:  B Schenk; F Fernandez; C J Waechter
Journal:  Glycobiology       Date:  2001-05       Impact factor: 4.313

3.  Transmembrane movement of oligosaccharide-lipids during glycoprotein synthesis.

Authors:  M D Snider; O C Rogers
Journal:  Cell       Date:  1984-03       Impact factor: 41.582

Review 4.  Roles of N-linked glycans in the endoplasmic reticulum.

Authors:  Ari Helenius; Markus Aebi
Journal:  Annu Rev Biochem       Date:  2004       Impact factor: 23.643

5.  Specific transbilayer translocation of dolichol-linked oligosaccharides by an endoplasmic reticulum flippase.

Authors:  Sumana Sanyal; Anant K Menon
Journal:  Proc Natl Acad Sci U S A       Date:  2009-01-07       Impact factor: 11.205

Review 6.  Flipping lipids: why an' what's the reason for?

Authors:  Sumana Sanyal; Anant K Menon
Journal:  ACS Chem Biol       Date:  2009-11-20       Impact factor: 5.100

7.  Structure and mechanism of an active lipid-linked oligosaccharide flippase.

Authors:  Camilo Perez; Sabina Gerber; Jérémy Boilevin; Monika Bucher; Tamis Darbre; Markus Aebi; Jean-Louis Reymond; Kaspar P Locher
Journal:  Nature       Date:  2015-08-12       Impact factor: 49.962

8.  Glycoprotein biosynthesis in a eukaryote lacking the membrane protein Rft1.

Authors:  Jennifer Jelk; Ningguo Gao; Mauro Serricchio; Aita Signorell; Remo S Schmidt; James D Bangs; Alvaro Acosta-Serrano; Mark A Lehrman; Peter Bütikofer; Anant K Menon
Journal:  J Biol Chem       Date:  2013-05-28       Impact factor: 5.157
  8 in total
  2 in total

Review 1.  Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping.

Authors:  Thomas Günther Pomorski; Anant K Menon
Journal:  Prog Lipid Res       Date:  2016-08-12       Impact factor: 16.195

Review 2.  Enzymatic trans-bilayer lipid transport: Mechanisms, efficiencies, slippage, and membrane curvature.

Authors:  Sankalp Shukla; Tobias Baumgart
Journal:  Biochim Biophys Acta Biomembr       Date:  2020-12-17       Impact factor: 3.747
  2 in total

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