P Gillet1, A Rapaille2, A Benoît3, M Ceinos3, O Bertrand2, I de Bouyalsky2, B Govaerts3, M Lambermont2. 1. Service du sang, Croix-Rouge de Belgique, Namur, Belgium. Electronic address: philippe.gillet@croix-rouge.be. 2. Service du sang, Croix-Rouge de Belgique, Namur, Belgium. 3. Institut de statistique, biostatistique et sciences actuarielles, université catholique de Louvain, Louvain-La-Neuve, Belgium.
Abstract
AIM OF THE STUDY: Whole blood donation is generally safe although vasovagal reactions can occur (approximately 1%). Risk factors are well known and prevention measures are shown as efficient. This study evaluates the impact of the donor's retention in relation to the occurrence of vasovagal reaction for the first three blood donations. MATERIAL AND METHODS: Our study of data collected over three years evaluated the impact of classical risk factors and provided a model including the best combination of covariates predicting VVR. The impact of a reaction at first donation on return rate and complication until the third donation was evaluated. RESULTS: Our data (523,471 donations) confirmed the classical risk factors (gender, age, donor status and relative blood volume). After stepwise variable selection, donor status, relative blood volume and their interaction were the only remaining covariates in the model. Of 33,279 first-time donors monitored over a period of at least 15 months, the first three donations were followed. Data emphasised the impact of complication at first donation. The return rate for a second donation was reduced and the risk of vasovagal reaction was increased at least until the third donation. CONCLUSION: First-time donation is a crucial step in the donors' career. Donors who experienced a reaction at their first donation have a lower return rate for a second donation and a higher risk of vasovagal reaction at least until the third donation. Prevention measures have to be processed to improve donor retention and provide blood banks with adequate blood supply.
AIM OF THE STUDY: Whole blood donation is generally safe although vasovagal reactions can occur (approximately 1%). Risk factors are well known and prevention measures are shown as efficient. This study evaluates the impact of the donor's retention in relation to the occurrence of vasovagal reaction for the first three blood donations. MATERIAL AND METHODS: Our study of data collected over three years evaluated the impact of classical risk factors and provided a model including the best combination of covariates predicting VVR. The impact of a reaction at first donation on return rate and complication until the third donation was evaluated. RESULTS: Our data (523,471 donations) confirmed the classical risk factors (gender, age, donor status and relative blood volume). After stepwise variable selection, donor status, relative blood volume and their interaction were the only remaining covariates in the model. Of 33,279 first-time donors monitored over a period of at least 15 months, the first three donations were followed. Data emphasised the impact of complication at first donation. The return rate for a second donation was reduced and the risk of vasovagal reaction was increased at least until the third donation. CONCLUSION: First-time donation is a crucial step in the donors' career. Donors who experienced a reaction at their first donation have a lower return rate for a second donation and a higher risk of vasovagal reaction at least until the third donation. Prevention measures have to be processed to improve donor retention and provide blood banks with adequate blood supply.
Authors: Edward Compton; Rachel Y Goldstein; Alexander Nazareth; Stephen J Shymon; Lydia Andras; Robert M Kay Journal: Medicine (Baltimore) Date: 2022-01-14 Impact factor: 1.817
Authors: Fernanda G M D Estrada; Claudia D L Oliveira; Ester C Sabino; Brian Custer; Thelma T Gonçalez; Edward L Murphy; Dahra Teles; Alfredo Mendrone-Junior; Steve S Witkin; Cesar de Almeida-Neto Journal: Transfus Med Date: 2020-05-28 Impact factor: 2.019