Marc Ruivard1, Fabrice Laine2, Yves Deugnier3. 1. Department of Internal Medicine, CHU Clermont-Ferrand, Clermont-Ferrand, France. 2. Centre d'Investigation Clinique INSERM 0203, CHU Pontchaillou, Rennes, France. 3. Centre d'Investigation Clinique INSERM 0203 and U522, CHU Pontchaillou, Rennes, France.