PURPOSE: To estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture. METHODS: We conducted a population-based case-control study. Cases were 6774 male enrollees in a large managed care organization, aged 45 or more years, with an incident hip fracture from 1997 to 2006. Controls without fracture (n = 6774) were matched to cases on age, race, and medical center. Electronic information on pharmaceutical use was used to identify the dispensing of statins from 1991 forward. RESULTS: Overall, 1884 (27.8%) cases and 2150 controls (31.7%) used a statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74-0.87). Adjustment for comorbidity burden strengthened the magnitude of the overall association (mOR = 0.68, CI = 0.62-0.74). The adjusted association was similar across age groups but was strongest among men aged 80 years or more (mOR = 0.62, CI = 0.54-0.71) and was most pronounced in African Americans (mOR = 0.43, CI = 0.28-0.64). Greater duration of statin use did not alter the odds ratios. CONCLUSIONS: These data add to the growing evidence of a potential protective effect of statin use on bone health. However, these results need to be replicated in a prospective study that can account for confounding by indication which may explain these findings.
PURPOSE: To estimate the association between hydroxymethylglutaryl-CoA inhibitor (statin) use and hip fracture. METHODS: We conducted a population-based case-control study. Cases were 6774 male enrollees in a large managed care organization, aged 45 or more years, with an incident hip fracture from 1997 to 2006. Controls without fracture (n = 6774) were matched to cases on age, race, and medical center. Electronic information on pharmaceutical use was used to identify the dispensing of statins from 1991 forward. RESULTS: Overall, 1884 (27.8%) cases and 2150 controls (31.7%) used a statin before index date (matched odds ratio [mOR] = 0.81, 95% confidence interval [CI] = 0.74-0.87). Adjustment for comorbidity burden strengthened the magnitude of the overall association (mOR = 0.68, CI = 0.62-0.74). The adjusted association was similar across age groups but was strongest among men aged 80 years or more (mOR = 0.62, CI = 0.54-0.71) and was most pronounced in African Americans (mOR = 0.43, CI = 0.28-0.64). Greater duration of statin use did not alter the odds ratios. CONCLUSIONS: These data add to the growing evidence of a potential protective effect of statin use on bone health. However, these results need to be replicated in a prospective study that can account for confounding by indication which may explain these findings.
Authors: Chandan Vangala; Colin R Lenihan; Maria E Montez-Rath; Sumi Sukumaran Nair; Sankar D Navaneethan; Venkat Ramanathan; Wolfgang C Winkelmayer Journal: BMC Nephrol Date: 2017-05-01 Impact factor: 2.388
Authors: Kyoung Jin Kim; Jimi Choi; Ji Yoon Kim; Jae Hyun Bae; Kyeong Jin Kim; Hee Young Kim; Hye Jin Yoo; Ji A Seo; Nan Hee Kim; Kyung Mook Choi; Sei Hyun Baik; Sin Gon Kim; Nam Hoon Kim Journal: J Lipid Atheroscler Date: 2021-07-06