Seyed-Foad Ahmadi1, Golara Zahmatkesh2, Elani Streja3, Rajnish Mehrotra4, Connie M Rhee2, Csaba P Kovesdy5, Daniel L Gillen6, Emad Ahmadi7, Gregg C Fonarow8, Kamyar Kalantar-Zadeh9. 1. Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, California, USA Department of Population Health and Disease Prevention, Program in Public Health, University of California Irvine, Irvine, California, USA. 2. Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, California, USA. 3. Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, California, USA Veterans Affairs Long Beach Healthcare System, Long Beach, California, USA. 4. Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, Washington, USA. 5. Memphis Veterans Affairs Medical Center, Memphis, Tennessee, USA Division of Nephrology, University of Tennessee Health Science Center, Memphis, Tennessee, USA. 6. Department of Population Health and Disease Prevention, Program in Public Health, University of California Irvine, Irvine, California, USA Department of Statistics, Donald Bren School of Information and Computer Sciences, University of California Irvine, Irvine, California, USA Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA. 7. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. 8. Division of Cardiology, UCLA David Geffen School of Medicine, Los Angeles, California, USA. 9. Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, California, USA Department of Population Health and Disease Prevention, Program in Public Health, University of California Irvine, Irvine, California, USA Veterans Affairs Long Beach Healthcare System, Long Beach, California, USA Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA kkz@uci.edu.
Abstract
UNLABELLED: ♦ BACKGROUND: Although higher body mass index (BMI) is associated with better outcomes in hemodialysis patients, the relationship in peritoneal dialysis (PD) patients is less clear. We aimed to synthesize the results from all large and high-quality studies to examine whether underweight, overweight, or obesity is associated with any significantly different risk of death in peritoneal dialysis patients. ♦ METHODS: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL, and screened 7,123 retrieved studies for inclusion. Two investigators independently selected the studies using predefined criteria and assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. We meta-analyzed the results of the largest studies with no overlap in their data sources. ♦ RESULTS: We included 9 studies (n = 156,562) in the systematic review and 4 studies in the meta-analyses. When examined without stratifying studies by follow-up duration, the results of the studies were inconsistent. Hence, we pooled the study results stratified based upon their follow-up durations, as suggested by a large study, and observed that being underweight was associated with higher 1-year mortality but had no significant association with 2- and 3- to 5-year mortalities. In contrast, being overweight or obese was associated with lower 1-year mortality but it had no significant association with 2-, and 3- to 5-year mortalities. ♦ CONCLUSION: Over the short-term, being underweight was associated with higher mortality and being overweight or obese was associated with lower mortality. The associations of body mass with mortality were not significant over the long-term.
UNLABELLED: ♦ BACKGROUND: Although higher body mass index (BMI) is associated with better outcomes in hemodialysis patients, the relationship in peritoneal dialysis (PD) patients is less clear. We aimed to synthesize the results from all large and high-quality studies to examine whether underweight, overweight, or obesity is associated with any significantly different risk of death in peritoneal dialysis patients. ♦ METHODS: We searched MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane CENTRAL, and screened 7,123 retrieved studies for inclusion. Two investigators independently selected the studies using predefined criteria and assessed each study's quality using the Newcastle-Ottawa Quality Assessment Scale. We meta-analyzed the results of the largest studies with no overlap in their data sources. ♦ RESULTS: We included 9 studies (n = 156,562) in the systematic review and 4 studies in the meta-analyses. When examined without stratifying studies by follow-up duration, the results of the studies were inconsistent. Hence, we pooled the study results stratified based upon their follow-up durations, as suggested by a large study, and observed that being underweight was associated with higher 1-year mortality but had no significant association with 2- and 3- to 5-year mortalities. In contrast, being overweight or obese was associated with lower 1-year mortality but it had no significant association with 2-, and 3- to 5-year mortalities. ♦ CONCLUSION: Over the short-term, being underweight was associated with higher mortality and being overweight or obese was associated with lower mortality. The associations of body mass with mortality were not significant over the long-term.
Authors: Kamyar Kalantar-Zadeh; Elani Streja; Csaba P Kovesdy; Antigone Oreopoulos; Nazanin Noori; Jennie Jing; Allen R Nissenson; Mahesh Krishnan; Joel D Kopple; Rajnish Mehrotra; Stefan D Anker Journal: Mayo Clin Proc Date: 2010-11 Impact factor: 7.616
Authors: Kamyar Kalantar-Zadeh; Kevin C Abbott; Abdulla K Salahudeen; Ryan D Kilpatrick; Tamara B Horwich Journal: Am J Clin Nutr Date: 2005-03 Impact factor: 7.045
Authors: Kevin C Abbott; Christopher W Glanton; Fernando C Trespalacios; David K Oliver; Maria I Ortiz; Lawrence Y Agodoa; David F Cruess; Paul L Kimmel Journal: Kidney Int Date: 2004-02 Impact factor: 10.612
Authors: Yoshitsugu Obi; Elani Streja; Rajnish Mehrotra; Matthew B Rivara; Connie M Rhee; Melissa Soohoo; Daniel L Gillen; Wei-Ling Lau; Csaba P Kovesdy; Kamyar Kalantar-Zadeh Journal: Am J Kidney Dis Date: 2017-12-07 Impact factor: 8.860
Authors: Seyed-Foad Ahmadi; Golara Zahmatkesh; Emad Ahmadi; Elani Streja; Connie M Rhee; Daniel L Gillen; Luca De Nicola; Roberto Minutolo; Ana C Ricardo; Csaba P Kovesdy; Kamyar Kalantar-Zadeh Journal: Cardiorenal Med Date: 2015-10-16 Impact factor: 2.041
Authors: Zhi Xu; Glen H Murata; Robert H Glew; Yijuan Sun; Darlene Vigil; Karen S Servilla; Antonios H Tzamaloukas Journal: World J Nephrol Date: 2017-05-06
Authors: Kamyar Kalantar-Zadeh; Connie M Rhee; Jason Chou; S Foad Ahmadi; Jongha Park; Joline Lt Chen; Alpesh N Amin Journal: Kidney Int Rep Date: 2017-02-01