| Literature DB >> 26475411 |
Abstract
CaMKII is activated by oxidation of methionine residues residing in the regulatory domain. Oxidized CaMKII (ox-CaMKII) is now thought to participate in cardiovascular and pulmonary diseases and cancer. This invited review summarizes current evidence for the role of ox-CaMKII in disease, considers critical knowledge gaps and suggests new areas for inquiry.Entities:
Keywords: Asthma; Atherosclerosis; Atrial fibrillation; CaMKII; Cancer; Heart failure; MsrA; Myocardial infarction; Sinus node dysfunction; Vascular smooth muscle; ox-CaMKII
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Year: 2015 PMID: 26475411 PMCID: PMC5075238 DOI: 10.1016/j.yjmcc.2015.10.014
Source DB: PubMed Journal: J Mol Cell Cardiol ISSN: 0022-2828 Impact factor: 5.000