| Literature DB >> 26473619 |
Marco Michele Mastandrea1, Niall Mellonie1, Pietro Giacinto1, Alba Collado2, Steven P Nolan2,3, Gian Pietro Miscione1,4, Andrea Bottoni1, Marco Bandini5.
Abstract
The intermolecular α-allylation of enals and enones occurs by the condensation of variously substituted allenamides with allylic alcohols. Cooperative catalysis by [Au(ItBu)NTf2] and AgNTf2 enables the synthesis of a range of densely functionalized α-allylated enals, enones, and acyl silanes in good yield under mild reaction conditions. DFT calculations support the role of an α-gold(I) enal/enone as the active nucleophilic species.Entities:
Keywords: alcohols; allylation; gold catalysis; reaction mechanisms; unsaturated carbonyl compounds
Year: 2015 PMID： 26473619 DOI： 10.1002/anie.201507218
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336