Christiane Pink1, Thomas Kocher1, Peter Meisel1, Marcus Dörr2,3, Marcello R P Markus2,3,4,5, Lukasz Jablonowski1, Anne Grotevendt6, Matthias Nauck6, Birte Holtfreter1. 1. Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Pedodontics and Primary Prevention, University Medicine Greifswald, Greifswald, Germany. 2. Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. 3. DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 4. Department Study of Health in Pomerania/Clinical-Epidemiological Research, Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 5. DZD (German Center for Diabetes Research), Partner Site Greifswald, Greifswald, Germany. 6. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Abstract
AIM: Systemic low-grade inflammation represents a central hallmark of chronic diseases and has been proposed as the underlying mechanism linking factors like obesity or diabetes with periodontitis. However, the impact of inflammatory markers on periodontitis has not yet been investigated. MATERIALS AND METHODS: The study population comprised 1784 subjects from the Study of Health in Pomerania with complete 11-year follow-up. Fibrinogen and white blood cell (WBC) counts were measured as markers of inflammation. Periodontitis was assessed by probing depth (PD), clinical attachment loss (CAL) and the CDC/AAP case definition. RESULTS: Multilevel regression analyses revealed significant coefficients for the impact of both inflammation markers on the percentage of sites with PD/CAL ≥ 3 mm. Increases in fibrinogen about 1 g/l were associated with 3.0% and 2.7% more sites with PD/CAL ≥ 3 mm respectively. Consistent associations were found using mean values of PD/CAL but not using missing teeth or caries. Regarding the CDC/AAP case definition, 11-year changes in fibrinogen and WBC counts were significantly associated with ≥1 category progression (OR: 1.36 and 1.11). CONCLUSIONS: Fibrinogen levels and WBC counts showed consistent long-term associations with PD, CAL and the CDC/AAP case definition. Results indicate that systemic low-grade inflammation might indeed represent one possible pathway for effects of obesity, diabetes or other chronic inflammatory conditions on periodontitis.
AIM: Systemic low-grade inflammation represents a central hallmark of chronic diseases and has been proposed as the underlying mechanism linking factors like obesity or diabetes with periodontitis. However, the impact of inflammatory markers on periodontitis has not yet been investigated. MATERIALS AND METHODS: The study population comprised 1784 subjects from the Study of Health in Pomerania with complete 11-year follow-up. Fibrinogen and white blood cell (WBC) counts were measured as markers of inflammation. Periodontitis was assessed by probing depth (PD), clinical attachment loss (CAL) and the CDC/AAP case definition. RESULTS: Multilevel regression analyses revealed significant coefficients for the impact of both inflammation markers on the percentage of sites with PD/CAL ≥ 3 mm. Increases in fibrinogen about 1 g/l were associated with 3.0% and 2.7% more sites with PD/CAL ≥ 3 mm respectively. Consistent associations were found using mean values of PD/CAL but not using missing teeth or caries. Regarding the CDC/AAP case definition, 11-year changes in fibrinogen and WBC counts were significantly associated with ≥1 category progression (OR: 1.36 and 1.11). CONCLUSIONS:Fibrinogen levels and WBC counts showed consistent long-term associations with PD, CAL and the CDC/AAP case definition. Results indicate that systemic low-grade inflammation might indeed represent one possible pathway for effects of obesity, diabetes or other chronic inflammatory conditions on periodontitis.
Authors: Cecilia C C Ribeiro; Cadidja D S Carmo; Bruno B Benatti; Renato V C Casarin; C M C Alves; Gustavo G Nascimento; A R O Moreira Journal: Clin Oral Investig Date: 2021-03-24 Impact factor: 3.573
Authors: Ahmed A Alhassani; Frank B Hu; Bernard A Rosner; Fred K Tabung; Walter C Willett; Kaumudi J Joshipura Journal: Br J Nutr Date: 2021-01-08 Impact factor: 3.718
Authors: Eileen Moritz; Gabriele Jedlitschky; Bernhard H Rauch; Birte Holtfreter; Josefine Negnal; Mladen V Tzvetkov; Günter Daum; Marcus Dörr; Stephan B Felix; Henry Völzke; Matthias Nauck; Edzard Schwedhelm; Peter Meisel; Thomas Kocher Journal: J Inflamm Res Date: 2021-06-30