Literature DB >> 26471967

Application of Fluorine in Drug Design During 2010-2015 Years: A Mini-Review.

Bao-Cheng Wang1, Li-Jun Wang1, Bo Jiang1, Shuai-Yu Wang1, Ning Wu1, Xiang-Qian Li1, Da-Yong Shi2.   

Abstract

BACKGROUND: The widespread application of fluorine in drug design benefits from distinctive properties. Incorporation of fluorine can positively modulate certain pharmacokinetics properties, including lipophilicity, eletrophilicity, metabolic stability, chemical stability, et al., which were of interest to medicinal chemists. Herein, fluorinated compounds, which have been designed and evaluated for anticancer, antimicrobial, anti-inflammatory and antivirus activity, et al. during the last 6 years (2010-2015) are summarized.
CONCLUSION: The emphasis is to highlight the importance of fluorinated compounds and the changes in the properties of compounds when introducing fluorine atom. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Application of fluorine; anti-inflammatory; anticancer; antimicrobial; antivirus activity; drug design; importance ofzzm321990fluorinated compounds

Mesh：

Substances：

Year:  2017        PMID： 26471967     DOI： 10.2174/1389557515666151016124957

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  6 in total

1.  Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2.

Authors:  Wu Bi; Ji-Chang Xiao; Rui-Jie Liu; Liu-Ying Zhou; Sai Zhang; Mei Yang; Peng-Fei Zhang
Journal:  Invest New Drugs       Date:  2019-05-11       Impact factor: 3.850

Review 2.  Catalytic stereoselective Mannich-type reactions for construction of fluorinated compounds.

Authors:  Minoo Dabiri; Noushin Farajinia Lehi; Reza Mohammadian
Journal:  Mol Divers       Date:  2021-07-06       Impact factor: 2.943

3.  Average orientation of a fluoroaromatic molecule in lipid bilayers from DFT-informed NMR measurements of 1H-19F dipolar couplings.

Authors:  Eleri Hughes; John M Griffin; Michael P Coogan; David A Middleton
Journal:  Phys Chem Chem Phys       Date:  2018-07-11       Impact factor: 3.676

4.  Synthesis of 1-(β-coumarinyl)-1-(β-indolyl)trifluoroethanols through regioselective Friedel-Crafts alkylation of indoles with β-(trifluoroacetyl)coumarins catalyzed by Sc(OTf)3.

Authors:  Lijun Shi; Ying Liu; Caixia Wang; Xinxin Yuan; Xiaobiao Liu; Lulu Wu; Zhenliang Pan; Qicheng Yu; Cuilian Xu; Guoyu Yang
Journal:  RSC Adv       Date:  2020-04-15       Impact factor: 4.036

5.  Curcumin derivative, 2,6-bis(2-fluorobenzylidene)cyclohexanone (MS65) inhibits interleukin-6 production through suppression of NF-κB and MAPK pathways in histamine-induced human keratinocytes cell (HaCaT).

Authors:  Nurul Atika Razali; Nur Amiza Nazarudin; Kok Song Lai; Faridah Abas; Syahida Ahmad
Journal:  BMC Complement Altern Med       Date:  2018-07-16       Impact factor: 3.659

Review 6.  Recent Studies on Fluorinated Silica Nanometer-Sized Particles.

Authors:  Scott T Iacono; Abby R Jennings
Journal:  Nanomaterials (Basel)       Date:  2019-05-02       Impact factor: 5.076
  6 in total

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