Søren Møller Madsen1, Anne Cathrine Thorup1, Kristian Overgaard2, Mette Bjerre3, Per Bendix Jeppesen1. 1. a Department of Endocrinology and Internal Medicine , Aarhus Sygehus THG, Aarhus University Hospital , Aarhus C , Denmark . 2. b Section of Sport Science, Department of Public Health, Aarhus University , Aarhus , Denmark , and. 3. c The Medical Research Laboratory, Department of Clinical Medicine, Faculty of Health, Aarhus University , Denmark.
Abstract
UNLABELLED: We wished to investigate the effects of 8 weeks of low volume high intensity interval training (HIIT) on endothelial function of popliteal artery and circulating cell adhesion molecules in type 2 diabetes (T2D) patients and matched controls (CON). METHODS: Over 8 weeks, non-active T2D patients and CONs cycled three times per week (10 × 60 sec HIIT). Pre- and post-HIIT measurements of endothelial function were conducted by applying flow-mediated dilation (FMD) along with taking venous blood samples. RESULTS: Baseline diameter of popliteal artery increased significantly from an average of 5.53 mm to 5.97 mm (∼8%) in the CON-group (p = 0.006) and 5.32 mm to 5.61 mm (∼6%) in the T2D-group (p = 0.009). Peak diameter increased significantly from 5.82 mm to 6.36 mm (∼9%) in the CON-group (p = 0.001) and 5.57 mm to 5.93 mm (∼7%) in the T2D-group (p = 0.004). FMD% increased significantly from 5.12% to 6.58% in the CON-group (p = 0.004) and 4.84% to 5.66% in the T2D-group: (p = 0.045). The shear rate reduced significantly in both groups (CON-group: p = 0.04; T2D-group: p = 0.002). Circulating cell adhesion molecules remained unchanged (p > 0.05). CONCLUSION: HIIT induced an improvement of endothelium-dependent FMD and significant outwards artery modelling. No changes in circulating cell adhesion molecules were observed.
UNLABELLED: We wished to investigate the effects of 8 weeks of low volume high intensity interval training (HIIT) on endothelial function of popliteal artery and circulating cell adhesion molecules in type 2 diabetes (T2D) patients and matched controls (CON). METHODS: Over 8 weeks, non-active T2D patients and CONs cycled three times per week (10 × 60 sec HIIT). Pre- and post-HIIT measurements of endothelial function were conducted by applying flow-mediated dilation (FMD) along with taking venous blood samples. RESULTS: Baseline diameter of popliteal artery increased significantly from an average of 5.53 mm to 5.97 mm (∼8%) in the CON-group (p = 0.006) and 5.32 mm to 5.61 mm (∼6%) in the T2D-group (p = 0.009). Peak diameter increased significantly from 5.82 mm to 6.36 mm (∼9%) in the CON-group (p = 0.001) and 5.57 mm to 5.93 mm (∼7%) in the T2D-group (p = 0.004). FMD% increased significantly from 5.12% to 6.58% in the CON-group (p = 0.004) and 4.84% to 5.66% in the T2D-group: (p = 0.045). The shear rate reduced significantly in both groups (CON-group: p = 0.04; T2D-group: p = 0.002). Circulating cell adhesion molecules remained unchanged (p > 0.05). CONCLUSION: HIIT induced an improvement of endothelium-dependent FMD and significant outwards artery modelling. No changes in circulating cell adhesion molecules were observed.
Entities:
Keywords:
Cell adhesion molecules; Type 2 diabetes; flow mediated dilation; high intensity interval training
Authors: Joyce S Ramos; Lance C Dalleck; Fabio Borrani; Alistair R Mallard; Bronwyn Clark; Shelley E Keating; Robert G Fassett; Jeff S Coombes Journal: Diabetologia Date: 2016-08-01 Impact factor: 10.122
Authors: José Gerosa-Neto; Barbara M M Antunes; Eduardo Z Campos; Jhennyfer Rodrigues; Gustavo D Ferrari; José C Rosa Neto; Carlos R Bueno; Fábio S Lira Journal: J Exerc Rehabil Date: 2016-12-31
Authors: Declan J Ryan; Jorgen A Wullems; Georgina K Stebbings; Christopher I Morse; Claire E Stewart; Gladys L Onambele-Pearson Journal: PLoS One Date: 2018-04-19 Impact factor: 3.240