Dong-Ping Cai1, Yong-Ming He2, Xiang-Jun Yang1, Xin Zhao1, Hai-Feng Xu1. 1. Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China. 2. Division of Cardiology, The First Affiliated Hospital of Soochow University, PR China. Electronic address: heyongming@suda.edu.cn.
Abstract
BACKGROUND: Lipoprotein (a) (Lp (a)) is a well-established risk factor for coronary artery disease (CAD) in Caucasians. However, data regarding the association of Lp (a) with CAD are lacking in Chinese Han population. METHODS: Cross-sectional study of 3462 cases and 6125 controls was performed for identifying the association of Lp (a) with CAD and its possible interactions with risk factors on CAD in Chinese. RESULTS: The Lp (a) levels in Chinese Han population were on average much lower than those in Caucasians. The suggested Lp (a) cutoff for discriminating CAD from non-CAD was 78.9 mg/dl. On a continuous or categorical scale, the odds ratios for CAD were almost consistently and significantly stepwise increased with the increased Lp (a) levels or quintiles in both genders. Significant interactions were found between Lp (a) and primary hypertension, body mass index, total cholesterol, and creatinin on CAD subdivisions. CONCLUSIONS: The Lp (a) distribution in Chinese Han population differs from that in Caucasian populations. The higher Lp (a) level is a confirmative risk factor for CAD, which can be modified by some risk factors in Chinese Han population. Our study provides direct evidence for differential approach to higher Lp (a) levels in Chinese.
BACKGROUND: Lipoprotein (a) (Lp (a)) is a well-established risk factor for coronary artery disease (CAD) in Caucasians. However, data regarding the association of Lp (a) with CAD are lacking in Chinese Han population. METHODS: Cross-sectional study of 3462 cases and 6125 controls was performed for identifying the association of Lp (a) with CAD and its possible interactions with risk factors on CAD in Chinese. RESULTS: The Lp (a) levels in Chinese Han population were on average much lower than those in Caucasians. The suggested Lp (a) cutoff for discriminating CAD from non-CAD was 78.9 mg/dl. On a continuous or categorical scale, the odds ratios for CAD were almost consistently and significantly stepwise increased with the increased Lp (a) levels or quintiles in both genders. Significant interactions were found between Lp (a) and primary hypertension, body mass index, total cholesterol, and creatinin on CAD subdivisions. CONCLUSIONS: The Lp (a) distribution in Chinese Han population differs from that in Caucasian populations. The higher Lp (a) level is a confirmative risk factor for CAD, which can be modified by some risk factors in Chinese Han population. Our study provides direct evidence for differential approach to higher Lp (a) levels in Chinese.
Authors: Chi Zhang; Bangming Cao; Xingmei Huang; Jian Gu; Ming Xia; Xiangjun Yang; Hongxia Li Journal: Iran J Public Health Date: 2020-07 Impact factor: 1.429