Sun Young Chae1, Chang-Min Choi2, Tae Sun Shim2, Yangsoon Park3, Chan-Sik Park3, Hyo Sang Lee1, Sang Ju Lee1, Seung Jun Oh1, Seog-Young Kim4, Sora Baek5, Norman Koglin6, Andrew W Stephens6, Ludger M Dinkelborg6, Dae Hyuk Moon7. 1. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 2. Department of Pulmonology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 3. Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Institute for Innovative Cancer Research, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. 5. Department of Nuclear Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Republic of Korea; and. 6. Piramal Imaging, Berlin, Germany. 7. Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea dhmoon@amc.seoul.kr.
Abstract
UNLABELLED: We explored system [Formula: see text] transporter activity and the detection of inflammatory or infectious lesions using (4S)-4-(3-(18)F-fluoropropyl)-l-glutamate ((18)F-FSPG) PET. METHODS: In 10 patients with various inflammatory or infectious diseases, as many as 5 of the largest lesions were selected as reference lesions. (18)F-FSPG images were assessed visually and quantitatively. Expression levels of xCT, CD44, and surface markers of inflammatory cells were evaluated by immunohistochemistry. RESULTS: (18)F-FSPG PET detected all reference lesions. (18)F-FSPG uptake in sarcoidosis was significantly higher than that in nonsarcoidosis. The lesion-to-blood-pool SUV ratio for (18)F-FSPG was comparable to that for (18)F-FDG in sarcoidosis. In nonsarcoidosis, however, it was significantly lower. In 5 patients with available tissue samples, the SUVmax for (18)F-FSPG and CD163 were negatively correlated (ρ = -0.872, P = 0.054). CONCLUSION: (18)F-FSPG PET may detect inflammatory lesions when activated macrophages or monocytes are present, such as in sarcoidosis.
UNLABELLED: We explored system [Formula: see text] transporter activity and the detection of inflammatory or infectious lesions using (4S)-4-(3-(18)F-fluoropropyl)-l-glutamate ((18)F-FSPG) PET. METHODS: In 10 patients with various inflammatory or infectious diseases, as many as 5 of the largest lesions were selected as reference lesions. (18)F-FSPG images were assessed visually and quantitatively. Expression levels of xCT, CD44, and surface markers of inflammatory cells were evaluated by immunohistochemistry. RESULTS: (18)F-FSPG PET detected all reference lesions. (18)F-FSPG uptake in sarcoidosis was significantly higher than that in nonsarcoidosis. The lesion-to-blood-pool SUV ratio for (18)F-FSPG was comparable to that for (18)F-FDG in sarcoidosis. In nonsarcoidosis, however, it was significantly lower. In 5 patients with available tissue samples, the SUVmax for (18)F-FSPG and CD163 were negatively correlated (ρ = -0.872, P = 0.054). CONCLUSION: (18)F-FSPG PET may detect inflammatory lesions when activated macrophages or monocytes are present, such as in sarcoidosis.
Authors: Mirwais Wardak; Ida Sonni; Audrey P Fan; Ryogo Minamimoto; Mehran Jamali; Negin Hatami; Greg Zaharchuk; Nancy Fischbein; Seema Nagpal; Gordon Li; Norman Koglin; Mathias Berndt; Santiago Bullich; Andrew W Stephens; Ludger M Dinkelborg; Ty Abel; H Charles Manning; Jarrett Rosenberg; Frederick T Chin; Sanjiv Sam Gambhir; Erik S Mittra Journal: Radiology Date: 2022-02-22 Impact factor: 29.146
Authors: Meaghan A Magarik; Ronald C Walker; Jill Gilbert; H Charles Manning; Pierre P Massion Journal: Clin Nucl Med Date: 2018-01 Impact factor: 7.794
Authors: Rafael Paez; Chirayu Shah; Angelina J Cords; Anel Muterspaugh; John E Helton; Sanja Antic; Rosana Eisenberg; Heidi Chen; Eric L Grogan; Henry C Manning; Ronald C Walker; Pierre P Massion Journal: PLoS One Date: 2022-03-16 Impact factor: 3.752