B J E de Lange-Brokaar1, J Bijsterbosch2, P R Kornaat3, E Yusuf2, A Ioan-Facsinay2, A-M Zuurmond4, H M Kroon5, I Meulenbelt6, J L Bloem5, M Kloppenburg7. 1. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands. Electronic address: b.j.e.de_lange@lumc.nl. 2. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands. 3. Department of Radiology, Bronovo Hospital, The Hague, The Netherlands. 4. TNO, Leiden, The Netherlands. 5. Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. 6. Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. 7. Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands.
Abstract
OBJECTIVE: To investigate patterns of MRI abnormalities in the patellofemoral (PFJ) and tibiofemoral joint (TFJ) and their association with radiographic progression, using hypothesis free analyses. DESIGN: 205 patients from the GARP study with symptomatic OA at multiple sites (mean age 60 years, 80% woman, median BMI 26 kg/m(2)), underwent knee MRI at baseline. Cartilage damage, osteophytes, cysts, bone marrow lesions (BMLs) and effusion/synovitis were scored according to a validated scoring method. Baseline and 6-year TFJ and PFJ radiographs were scored (0-3) for JSN and osteophytes according to OARSI and Burnett atlases, respectively; progression was defined as ≥1 point increase. Baseline patterns of MRI abnormalities derived from principal component analysis (PCA) were associated with progression using adjusted generalized estimating equations (GEE). RESULTS: PCA resulted in extraction of six components, explaining 69% of variance. In 29% and 29% of 133 patients with follow-up the TFJ progressed, whereas in 15% and 9% the PFJ progressed for osteophytes and JSN, respectively. Component 1 (cartilage damage of the PFJ and osteophytes of both joints) was statistically significant associated with TFJ JSN progression and PFJ osteophyte progression. Component 2 (all lateral PFJ abnormalities except osteophytes) was associated with JSN/osteophyte progression in the PFJ alone, whereas component 3 (all medial TFJ abnormalities except osteophytes) was associated with JSN and osteophyte progression in both PFJ and TFJ. CONCLUSION: Baseline structural damage and bone turnover activity, as reflected by BMLs, seem to be involved in knee OA progression. Moreover, progression in PFJ and TFJ seems to be related.
OBJECTIVE: To investigate patterns of MRI abnormalities in the patellofemoral (PFJ) and tibiofemoral joint (TFJ) and their association with radiographic progression, using hypothesis free analyses. DESIGN: 205 patients from the GARP study with symptomatic OA at multiple sites (mean age 60 years, 80% woman, median BMI 26 kg/m(2)), underwent knee MRI at baseline. Cartilage damage, osteophytes, cysts, bone marrow lesions (BMLs) and effusion/synovitis were scored according to a validated scoring method. Baseline and 6-year TFJ and PFJ radiographs were scored (0-3) for JSN and osteophytes according to OARSI and Burnett atlases, respectively; progression was defined as ≥1 point increase. Baseline patterns of MRI abnormalities derived from principal component analysis (PCA) were associated with progression using adjusted generalized estimating equations (GEE). RESULTS: PCA resulted in extraction of six components, explaining 69% of variance. In 29% and 29% of 133 patients with follow-up the TFJ progressed, whereas in 15% and 9% the PFJ progressed for osteophytes and JSN, respectively. Component 1 (cartilage damage of the PFJ and osteophytes of both joints) was statistically significant associated with TFJ JSN progression and PFJ osteophyte progression. Component 2 (all lateral PFJ abnormalities except osteophytes) was associated with JSN/osteophyte progression in the PFJ alone, whereas component 3 (all medial TFJ abnormalities except osteophytes) was associated with JSN and osteophyte progression in both PFJ and TFJ. CONCLUSION: Baseline structural damage and bone turnover activity, as reflected by BMLs, seem to be involved in knee OA progression. Moreover, progression in PFJ and TFJ seems to be related.
Authors: Nima Hafezi-Nejad; Ali Guermazi; Frank W Roemer; David J Hunter; Erik B Dam; Bashir Zikria; C Kent Kwoh; Shadpour Demehri Journal: Eur Radiol Date: 2016-05-24 Impact factor: 5.315
Authors: Mukundan Attur; Svetlana Krasnokutsky; Hua Zhou; Jonathan Samuels; Gregory Chang; Jenny Bencardino; Pamela Rosenthal; Leon Rybak; Janet L Huebner; Virginia B Kraus; Steven B Abramson Journal: Arthritis Res Ther Date: 2020-09-10 Impact factor: 5.156