Katarzyna Nowomiejska1, Agnieszka Brzozowska2, Michael J Koss3, Richard G Weleber4, Ulrich Schiefer5, Konrad Rejdak6, Anselm G Juenemann7, Ryszard Maciejewski8, Robert Rejdak1,9. 1. a Department of General Ophthalmology , Medical University in Lublin , Poland. 2. b Department of Mathematics and Medical Biostatistics , Medical University , Lublin , Poland. 3. c Department of Ophthalmology , University of Heidelberg , Heidelberg , Germany. 4. d Casey Eye Institute Oregon Retinal Degeneration Center, Oregon Health & Science University , Portland , USA. 5. e Centre for Ophthalmology/Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany; Competence Centre "Vision Research", University of Applied Science , Aalen , Germany. 6. f Department of Neurology , Medical University , Lublin , Poland. 7. g Department of Ophthalmology , University of Rostock , Rostock , Germany. 8. h Human Anatomy Department , Medical University , Lublin , Poland. 9. i Department of Experimental Pharmacology , Medical Research Centre, Polish Academy of Sciences , Warsaw , Poland.
Abstract
PURPOSE: To assess quantitatively the natural course of the visual field (VF) loss in patients with retinitis pigmentosa (RP) during 2-year period of observation. METHODS: VFs were obtained by semi-automated kinetic perimetry (SKP) during four examinations of 16 patients suffering from RP. Three stimulus conditions (V4e, III4e and I4e) with a constant stimulus angular velocity of 3°/s were used to assess the hill of vision in both eyes of each patient. The area of each isopter was measured in square degrees and corrected for the individual reaction time (RT). RESULTS: There were four patients with mild restriction of VF, six with ring scotomas and six with advanced concentric constrictions of VF. Only I4e isopter area decreased significantly from the first to the last session (p = 0.006), the difference was 154 deg(2) being 13% of initial isopter area. The difference was not significant for V4e and III4e isopters. RT values did not differ significantly between four sessions. CONCLUSIONS: Only I4e isopter's area was decreased significantly during two years of observation. SKP provides a method of assessment of progression of the VF loss in patients suffering from RP by measurement of the isopters' area over time.
PURPOSE: To assess quantitatively the natural course of the visual field (VF) loss in patients with retinitis pigmentosa (RP) during 2-year period of observation. METHODS: VFs were obtained by semi-automated kinetic perimetry (SKP) during four examinations of 16 patients suffering from RP. Three stimulus conditions (V4e, III4e and I4e) with a constant stimulus angular velocity of 3°/s were used to assess the hill of vision in both eyes of each patient. The area of each isopter was measured in square degrees and corrected for the individual reaction time (RT). RESULTS: There were four patients with mild restriction of VF, six with ring scotomas and six with advanced concentric constrictions of VF. Only I4e isopter area decreased significantly from the first to the last session (p = 0.006), the difference was 154 deg(2) being 13% of initial isopter area. The difference was not significant for V4e and III4e isopters. RT values did not differ significantly between four sessions. CONCLUSIONS: Only I4e isopter's area was decreased significantly during two years of observation. SKP provides a method of assessment of progression of the VF loss in patients suffering from RP by measurement of the isopters' area over time.
Entities:
Keywords:
Isopter; perimetry; reaction time; retinitis pigmentosa; visual field
Authors: Claire S Barnes; Ronald A Schuchard; David G Birch; Gislin Dagnelie; Leah Wood; Robert K Koenekoop; Ava K Bittner Journal: Transl Vis Sci Technol Date: 2019-06-11 Impact factor: 3.283