| Literature DB >> 26470815 |
C P Peters1, J M Mjösberg2, J H Bernink3, H Spits4.
Abstract
It is generally believed that inflammatory bowel diseases (IBD) are caused by an aberrant immune response to environmental triggers in genetically susceptible individuals. The exact contribution of the adaptive and innate immune system has not been elucidated. However, recent advances in treatments targeting key inflammatory mediators such as tumour necrosis factor highlight the crucial role of the innate immune system in IBD. Innate lymphoid cells (ILCs) have recently been identified to play an important role in immune mediated inflammatory diseases. In this review we recapitulate the current knowledge on ILCs in IBD.Entities:
Keywords: Anti-TNF; Crohn’s disease; IBD; IFN-γ; ILC; Innate lymphoid cells; Ulcerative colitis
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Year: 2015 PMID： 26470815 DOI： 10.1016/j.imlet.2015.10.004
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685