Andrei Brateanu1,2, Michael B Rothberg3,4. 1. Department of Internal Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. E-mail: abratean@ccf.org. 2. Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. 3. Vice Chair for Research, Medicine Institute, Cleveland Clinic, Cleveland, OH, USA. 4. Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.