PURPOSE: To use optical coherence tomography (OCT) angiography to monitor the short-term blood flow changes in choroidal neovascularization (CNV) in response to treatment. METHODS: In this retrospective report, a case of exudative CNV was followed closely with OCT angiography over three cycles of antiangiogenic treatment. Outer retinal flow index, CNV flow area and central macular retinal thickness were measured. RESULTS: Quantitative measurements of CNV flow area and flow index showed rapid shutdown of flow over the initial 2 weeks, followed by reappearance of CNV channel by the fourth week, preceding fluid reaccumulation at 6 weeks. CONCLUSION: Frequent OCT angiography reveals a previously unknown pattern of rapid shutdown and reappearance of CNV channels within treatment cycles. OCT angiographic changes precede fluid reaccumulation and could be useful as leading indicators of CNV activity that could guide treatment timing. Further studies using OCT angiography in short intervals between antiangiogenic treatments are needed.
PURPOSE: To use optical coherence tomography (OCT) angiography to monitor the short-term blood flow changes in choroidal neovascularization (CNV) in response to treatment. METHODS: In this retrospective report, a case of exudative CNV was followed closely with OCT angiography over three cycles of antiangiogenic treatment. Outer retinal flow index, CNV flow area and central macular retinal thickness were measured. RESULTS: Quantitative measurements of CNV flow area and flow index showed rapid shutdown of flow over the initial 2 weeks, followed by reappearance of CNV channel by the fourth week, preceding fluid reaccumulation at 6 weeks. CONCLUSION: Frequent OCT angiography reveals a previously unknown pattern of rapid shutdown and reappearance of CNV channels within treatment cycles. OCT angiographic changes precede fluid reaccumulation and could be useful as leading indicators of CNV activity that could guide treatment timing. Further studies using OCT angiography in short intervals between antiangiogenic treatments are needed.
Authors: Yali Jia; Steven T Bailey; Thomas S Hwang; Scott M McClintic; Simon S Gao; Mark E Pennesi; Christina J Flaxel; Andreas K Lauer; David J Wilson; Joachim Hornegger; James G Fujimoto; David Huang Journal: Proc Natl Acad Sci U S A Date: 2015-04-20 Impact factor: 11.205
Authors: Philip J Rosenfeld; David M Brown; Jeffrey S Heier; David S Boyer; Peter K Kaiser; Carol Y Chung; Robert Y Kim Journal: N Engl J Med Date: 2006-10-05 Impact factor: 91.245
Authors: Yali Jia; Steven T Bailey; David J Wilson; Ou Tan; Michael L Klein; Christina J Flaxel; Benjamin Potsaid; Jonathan J Liu; Chen D Lu; Martin F Kraus; James G Fujimoto; David Huang Journal: Ophthalmology Date: 2014-03-27 Impact factor: 12.079
Authors: Talisa E de Carlo; Marco A Bonini Filho; Adam T Chin; Mehreen Adhi; Daniela Ferrara; Caroline R Baumal; Andre J Witkin; Elias Reichel; Jay S Duker; Nadia K Waheed Journal: Ophthalmology Date: 2015-03-17 Impact factor: 12.079
Authors: Gary Shienbaum; Omesh P Gupta; Christopher Fecarotta; Avni H Patel; Richard S Kaiser; Carl D Regillo Journal: Am J Ophthalmol Date: 2011-10-11 Impact factor: 5.258
Authors: Daniel F Martin; Maureen G Maguire; Gui-shuang Ying; Juan E Grunwald; Stuart L Fine; Glenn J Jaffe Journal: N Engl J Med Date: 2011-04-28 Impact factor: 91.245
Authors: Martin F Kraus; Benjamin Potsaid; Markus A Mayer; Ruediger Bock; Bernhard Baumann; Jonathan J Liu; Joachim Hornegger; James G Fujimoto Journal: Biomed Opt Express Date: 2012-05-03 Impact factor: 3.732
Authors: Yali Jia; Ou Tan; Jason Tokayer; Benjamin Potsaid; Yimin Wang; Jonathan J Liu; Martin F Kraus; Hrebesh Subhash; James G Fujimoto; Joachim Hornegger; David Huang Journal: Opt Express Date: 2012-02-13 Impact factor: 3.894
Authors: Jie Wang; Miao Zhang; Thomas S Hwang; Steven T Bailey; David Huang; David J Wilson; Yali Jia Journal: Biomed Opt Express Date: 2017-02-15 Impact factor: 3.732
Authors: Vaël Souedan; Eric H Souied; Violaine Caillaux; Alexandra Miere; Ala El Ameen; Rocio Blanco-Garavito Journal: Int Ophthalmol Date: 2017-05-25 Impact factor: 2.031
Authors: Simon S Gao; Li Liu; Steven T Bailey; Christina J Flaxel; David Huang; Dengwang Li; Yali Jia Journal: J Biomed Opt Date: 2016-07-01 Impact factor: 3.170
Authors: Miao Zhang; Thomas S Hwang; J Peter Campbell; Steven T Bailey; David J Wilson; David Huang; Yali Jia Journal: Biomed Opt Express Date: 2016-02-09 Impact factor: 3.732
Authors: Emma C Zanzottera; Thomas Ach; Carrie Huisingh; Jeffrey D Messinger; K Bailey Freund; Christine A Curcio Journal: Retina Date: 2016-12 Impact factor: 4.256
Authors: S Tammy Hsu; Hoan T Ngo; Sandra S Stinnett; Nathan L Cheung; Robert J House; Michael P Kelly; Xi Chen; Laura B Enyedi; S Grace Prakalapakorn; Miguel A Materin; Mays A El-Dairi; Glenn J Jaffe; Sharon F Freedman; Cynthia A Toth; Lejla Vajzovic Journal: Ophthalmology Date: 2019-07-15 Impact factor: 12.079