Gian Paolo Fadini1, Benedetta Maria Bonora1, Giorgio Marcuzzo1, Maria Cristina Marescotti1, Roberta Cappellari1, Giorgia Pantano1, Maria Colomba Sanzari1, Xavier Duran1, Joan Vendrell1, Mario Plebani1, Angelo Avogaro1. 1. Department of Medicine (G.P.F., B.M.B., M.C.M., R.C., G.P., M.C.S., M.P., A.A.), University of Padova, 35128 Padova, Italy; Venetian Institute of Molecular Medicine (G.P.F., X.D., A.A.), 35128 Padova, Italy; Department of Cardiologic, Thoracic and Vascular Sciences (G.M.), Service of Preventive Medicine, University of Padova, 35128 Padova, Italy; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) (X.D., J.V.), Instituto de Salud Carlos III, Madrid, Spain; Joan XXIII University Hospital (J.V.), Rovira i Virgili University IISPV, Tarragona, Spain.
Abstract
CONTEXT: Obesity and metabolic syndrome are associated with mild leukocytosis, but whether hematopoietic stem/progenitor cells (HSPCs) play a role in metabolic deterioration is unknown. OBJECTIVE: Our objective was to analyze the cross-sectional and longitudinal associations between CD34(+) HSPCs, adiposity, and metabolic syndrome features. DESIGN: This is a cross-sectional study on 242 participants, 155 of whom were followed and included in a longitudinal assessment. SETTING: This study took place in a tertiary referral center for metabolic diseases. PARTICIPANTS: Healthy working individuals attending a cardiovascular screening program (total n = 3158) and having a baseline measure of circulating CD34(+) cells participated. MAIN OUTCOME MEASURES: We collected demographic and anthropometric data, cardiovascular risk factors, and metabolic syndrome parameters. RESULTS: Participants (34.7% males, mean age 45.9 ± 0.5 years) were free from diabetes and cardiovascular disease. Cross-sectionally, absolute CD34(+) cell counts were directly correlated with body mass index and waist circumference, inversely correlated with high-density lipoprotein cholesterol and the quantitative insulin sensitivity check index, and were higher in individuals with the metabolic syndrome. The hematopoietic component contributed most to the association of CD34(+) cells with adiposity. During a 6.3-year follow-up, high absolute levels of CD34(+) cells were associated with increasing waist circumference, declining quantitative insulin sensitivity check index and high-density lipoprotein cholesterol, and with incidence of metabolic syndrome. Relative CD34(+) cell counts showed weaker associations with metabolic parameters than absolute levels, but were longitudinally associated with increasing waist circumference and metabolic syndrome development. CONCLUSIONS: A mild elevation of circulating CD34(+) progenitor cells, reflecting expansion of HSPCs, is associated with adiposity and future metabolic deterioration in healthy individuals.
CONTEXT: Obesity and metabolic syndrome are associated with mild leukocytosis, but whether hematopoietic stem/progenitor cells (HSPCs) play a role in metabolic deterioration is unknown. OBJECTIVE: Our objective was to analyze the cross-sectional and longitudinal associations between CD34(+) HSPCs, adiposity, and metabolic syndrome features. DESIGN: This is a cross-sectional study on 242 participants, 155 of whom were followed and included in a longitudinal assessment. SETTING: This study took place in a tertiary referral center for metabolic diseases. PARTICIPANTS: Healthy working individuals attending a cardiovascular screening program (total n = 3158) and having a baseline measure of circulating CD34(+) cells participated. MAIN OUTCOME MEASURES: We collected demographic and anthropometric data, cardiovascular risk factors, and metabolic syndrome parameters. RESULTS:Participants (34.7% males, mean age 45.9 ± 0.5 years) were free from diabetes and cardiovascular disease. Cross-sectionally, absolute CD34(+) cell counts were directly correlated with body mass index and waist circumference, inversely correlated with high-density lipoprotein cholesterol and the quantitative insulin sensitivity check index, and were higher in individuals with the metabolic syndrome. The hematopoietic component contributed most to the association of CD34(+) cells with adiposity. During a 6.3-year follow-up, high absolute levels of CD34(+) cells were associated with increasing waist circumference, declining quantitative insulin sensitivity check index and high-density lipoprotein cholesterol, and with incidence of metabolic syndrome. Relative CD34(+) cell counts showed weaker associations with metabolic parameters than absolute levels, but were longitudinally associated with increasing waist circumference and metabolic syndrome development. CONCLUSIONS: A mild elevation of circulating CD34(+) progenitor cells, reflecting expansion of HSPCs, is associated with adiposity and future metabolic deterioration in healthy individuals.
Authors: Nick Marcks; Alberto Aimo; James L Januzzi; Giuseppe Vergaro; Aldo Clerico; Roberto Latini; Jennifer Meessen; Inder S Anand; Jay N Cohn; Jørgen Gravning; Thor Ueland; Antoni Bayes-Genis; Josep Lupón; Rudolf A de Boer; Akiomi Yoshihisa; Yasuchika Takeishi; Michael Egstrup; Ida Gustafsson; Hanna K Gaggin; Kai M Eggers; Kurt Huber; Ioannis Tentzeris; Andrea Ripoli; Claudio Passino; Sandra Sanders-van Wijk; Michele Emdin; Hans-Peter Brunner-La Rocca Journal: Clin Res Cardiol Date: 2021-03-11 Impact factor: 6.138
Authors: Ehab Bakbak; Daniella C Terenzi; Justin Z Trac; Hwee Teoh; Adrian Quan; Stephen A Glazer; Ori D Rotstein; Mohammed Al-Omran; Subodh Verma; David A Hess Journal: Rev Endocr Metab Disord Date: 2021-07-06 Impact factor: 6.514