Liaqat Hussain1, Muhammad S H Akash2, Sabah Naseem1, Kanwal Rehman3, Kwaja Z Ahmed1. 1. Government College, University Faisalabad, Pakistan. 2. College of Pharmaceutical Sciences, Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China. 3. Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou, China.
Abstract
BACKGROUND: According to an estimation of the WHO, almost 80% of people globally are treated by traditional medicine. OBJECTIVES: We evaluated the anti-ulcerogenic potential of Salmalia malabarica extract in rats using aspirin-, alcohol- and pylorus ligation-induced ulcer models. MATERIAL AND METHODS: Two different doses (200 and 400 mg/kg body weight) of Salmalia malabarica extract was administered intraperitoneally (i.p.) to all 3 ulcer-induced models for 5 consecutive days. The anti-ulcerogenic potential in rats treated with 2 doses of Salmalia malabarica extract and omeprazole (20 mg/kg, i.p.) was determined and compared to the control groups. RESULTS: Salmalia malabarica extract showed a significant decrease in ulcer index as compared to the control group in a dose-dependent manner. Salmalia malabarica extract also showed protection of 66.22% and 74.54% in asprin-, 73.79% and 78.14% in alcohol- and 68.94% and 78.84% in pylorus ligation-induced ulcers. However, omeprazole showed protection of 84.73%, 85.5% and 86.12% in aspirin-, alcohol- and pylorus ligation-induced ulcers, respectively. Furthermore, Salmalia malabarica extract significantly decreased the volume of gastric juice, free and total acidity, whereas it increased gastric pH when directly compared to the control group. CONCLUSIONS: Conclusively, Salmalia malabarica possesses anti-ulcerogenic, antisecretory, and cytoprotective potential and can be used as a supplement for the treatment of gastric ulcers in a dose dependent manner.
BACKGROUND: According to an estimation of the WHO, almost 80% of people globally are treated by traditional medicine. OBJECTIVES: We evaluated the anti-ulcerogenic potential of Salmalia malabarica extract in rats using aspirin-, alcohol- and pylorus ligation-induced ulcer models. MATERIAL AND METHODS: Two different doses (200 and 400 mg/kg body weight) of Salmalia malabarica extract was administered intraperitoneally (i.p.) to all 3 ulcer-induced models for 5 consecutive days. The anti-ulcerogenic potential in rats treated with 2 doses of Salmalia malabarica extract and omeprazole (20 mg/kg, i.p.) was determined and compared to the control groups. RESULTS:Salmalia malabarica extract showed a significant decrease in ulcer index as compared to the control group in a dose-dependent manner. Salmalia malabarica extract also showed protection of 66.22% and 74.54% in asprin-, 73.79% and 78.14% in alcohol- and 68.94% and 78.84% in pylorus ligation-induced ulcers. However, omeprazole showed protection of 84.73%, 85.5% and 86.12% in aspirin-, alcohol- and pylorus ligation-induced ulcers, respectively. Furthermore, Salmalia malabarica extract significantly decreased the volume of gastric juice, free and total acidity, whereas it increased gastric pH when directly compared to the control group. CONCLUSIONS: Conclusively, Salmalia malabarica possesses anti-ulcerogenic, antisecretory, and cytoprotective potential and can be used as a supplement for the treatment of gastric ulcers in a dose dependent manner.
Authors: Asiya Bashir; Muhammad Asif; Malik Saadullah; Mohammad Saleem; Syed Haroon Khalid; Liaqat Hussain; Ikram Ullah Khan; Hafiza Sidra Yaseen; Hafiz Muhammad Zubair; Muhammad Usman Shamas; Raghdaa Al Zarzour; Tahir Ali Chohan Journal: ACS Omega Date: 2022-07-15