Pieta R Winter 1 , Tinte Itinteang 1 , Phillip Leadbitter 1,2,3 , Swee T Tan 1,2 Show Affiliations »
Abstract
UNLABELLED: PHACE syndrome comprises a spectrum of anomalies including posterior fossa malformations, haemangioma, arterial anomalies, cardiac defects and eye anomalies. PHACE should be considered in any patient with a large facial segmental infantile haemangioma (IH), and multidisciplinary management is crucial. Low-dose propranolol is effectively for the treatment of IH associated with PHACE syndrome. Recent evidence suggests IH is comprised of mesoderm-derived haemogenic endothelium. CONCLUSION: The embryonic developmental anomaly nature of IH provides an insight into the origin of PHACE syndrome. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
UNLABELLED: PHACE syndrome comprises a spectrum of anomalies including posterior fossa malformations , haemangioma, arterial anomalies , cardiac defects and eye anomalies . PHACE should be considered in any patient with a large facial segmental infantile haemangioma (IH), and multidisciplinary management is crucial. Low-dose propranolol is effectively for the treatment of IH associated with PHACE syndrome. Recent evidence suggests IH is comprised of mesoderm-derived haemogenic endothelium. CONCLUSION: The embryonic developmental anomaly nature of IH provides an insight into the origin of PHACE syndrome. ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Entities: Chemical
Disease
Species
Keywords:
Aetiology; Infantile haemangioma; PHACE syndrome; Renin-angiotensin system; β-blockers
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Year: 2015
PMID： 26469095 DOI： 10.1111/apa.13242
Source DB: PubMed Journal: Acta Paediatr ISSN： 0803-5253 Impact factor: 2.299