Literature DB >> 26468526

Crystal Structure of the Conserved Amino Terminus of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus Gripped by an Antibody.

Ki Joon Cho1, Bert Schepens1, Kristof Moonens2, Lei Deng1, Walter Fiers1, Han Remaut2, Xavier Saelens3.   

Abstract

We report the crystal structure of the M2 ectodomain (M2e) in complex with a monoclonal antibody that binds the amino terminus of M2. M2e extends into the antibody binding site to form an N-terminal β-turn near the bottom of the paratope. This M2e folding differs significantly from that of M2e in complex with an antibody that binds another part of M2e. This suggests that M2e can adopt at least two conformations that can elicit protective antibodies.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26468526      PMCID： PMC4702545          DOI： 10.1128/JVI.02105-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

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Journal:  Proteins       Date:  2003-02-15

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Journal:  Structure       Date:  2002-07       Impact factor: 5.006

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Authors:  Jennifer Serrière; Jean-Marc Dugua; Marc Bossus; Bernard Verrier; Richard Haser; Patrice Gouet; Christophe Guillon
Journal:  J Mol Biol       Date:  2010-10-28       Impact factor: 5.469

4.  Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus.

Authors:  Tong-Ming Fu; Daniel C Freed; Melanie S Horton; Jiang Fan; Michael P Citron; Joseph G Joyce; Victor M Garsky; Danilo R Casimiro; Qinjian Zhao; John W Shiver; Xiaoping Liang
Journal:  Virology       Date:  2008-12-13       Impact factor: 3.616

5.  Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface.

Authors:  R A Lamb; S L Zebedee; C D Richardson
Journal:  Cell       Date:  1985-03       Impact factor: 41.582

6.  Human antibodies reveal a protective epitope that is highly conserved among human and nonhuman influenza A viruses.

Authors:  Andres G Grandea; Ole A Olsen; Thomas C Cox; Mark Renshaw; Philip W Hammond; Po-Ying Chan-Hui; Jennifer L Mitcham; Witold Cieplak; Shaun M Stewart; Michael L Grantham; Andrew Pekosz; Maki Kiso; Kyoko Shinya; Masato Hatta; Yoshihiro Kawaoka; Matthew Moyle
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-01       Impact factor: 11.205

7.  Therapeutic potential of a fully human monoclonal antibody against influenza A virus M2 protein.

Authors:  Rongfang Wang; Aihua Song; James Levin; Dawna Dennis; Noelle J Zhang; Hitoshi Yoshida; Lilia Koriazova; Lydia Madura; Laura Shapiro; Atsushi Matsumoto; Hideaki Yoshida; Toshifumi Mikayama; Ralph T Kubo; Sally Sarawar; Hilde Cheroutre; Shinichiro Kato
Journal:  Antiviral Res       Date:  2008-07-01       Impact factor: 5.970

8.  Efficacy and safety of treatment with an anti-m2e monoclonal antibody in experimental human influenza.

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Journal:  J Infect Dis       Date:  2014-10-03       Impact factor: 5.226

9.  Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2.

Authors:  J Tormo; D Blaas; N R Parry; D Rowlands; D Stuart; I Fita
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598

10.  Phaser crystallographic software.

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Journal:  J Appl Crystallogr       Date:  2007-07-13       Impact factor: 3.304
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  12 in total

1.  M2e-tetramer-specific memory CD4 T cells are broadly protective against influenza infection.

Authors:  D G Eliasson; A Omokanye; K Schön; U A Wenzel; V Bernasconi; M Bemark; A Kolpe; K El Bakkouri; T Ysenbaert; L Deng; W Fiers; X Saelens; N Lycke
Journal:  Mucosal Immunol       Date:  2017-03-01       Impact factor: 7.313

Review 2.  Antibody-Mediated Catalysis in Infection and Immunity.

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Journal:  Infect Immun       Date:  2017-08-18       Impact factor: 3.441

3.  The Influenza M2 Ectodomain Regulates the Conformational Equilibria of the Transmembrane Proton Channel: Insights from Solid-State Nuclear Magnetic Resonance.

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Journal:  Biochemistry       Date:  2016-09-12       Impact factor: 3.162

4.  Tetramerizing tGCN4 domain facilitates production of Influenza A H1N1 M2e higher order soluble oligomers that show enhanced immunogenicity in vivo.

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Journal:  J Biol Chem       Date:  2020-08-13       Impact factor: 5.157

5.  Nanovaccine Confers Dual Protection Against Influenza A Virus And Porcine Circovirus Type 2.

Authors:  Peiyang Ding; Qianyue Jin; Xinxin Chen; Suzhen Yang; Junqing Guo; Guangxu Xing; Ruiguang Deng; Aiping Wang; Gaiping Zhang
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6.  Matrix Protein 2 Extracellular Domain-Specific Monoclonal Antibodies Are an Effective and Potentially Universal Treatment for Influenza A.

Authors:  Lynn Bimler; Sydney L Ronzulli; Amber Y Song; Scott K Johnson; Cheryl A Jones; Teha Kim; Duy T Le; S Mark Tompkins; Silke Paust
Journal:  J Virol       Date:  2020-12-02       Impact factor: 6.549

7.  The Role of Matrix Protein 2 Ectodomain in the Development of Universal Influenza Vaccines.

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Journal:  J Infect Dis       Date:  2019-04-08       Impact factor: 5.226

8.  Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection.

Authors:  Dorien De Vlieger; Katja Hoffmann; Inge Van Molle; Wim Nerinckx; Lien Van Hoecke; Marlies Ballegeer; Sarah Creytens; Han Remaut; Hartmut Hengel; Bert Schepens; Xavier Saelens
Journal:  Front Immunol       Date:  2019-12-12       Impact factor: 7.561

Review 9.  Influenza A Virus M2 Protein: Roles from Ingress to Egress.

Authors:  Rashid Manzoor; Manabu Igarashi; Ayato Takada
Journal:  Int J Mol Sci       Date:  2017-12-07       Impact factor: 5.923

Review 10.  M2e-based universal influenza vaccines: a historical overview and new approaches to development.

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Journal:  J Biomed Sci       Date:  2019-10-19       Impact factor: 8.410
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