Literature DB >> 26468498

Preliminary Evaluation of the Research-Use-Only (RUO) iCubate iC-GPC Assay for Identification of Select Gram-Positive Bacteria and Their Resistance Determinants in Blood Culture Broths.

Blake W Buchan1, Garrett C Reymann2, Paul A Granato3, Brenda R Alkins4, Patricia Jim5, Stephen Young6.   

Abstract

The iC-GPC assay (iCubate, Huntsville, AL) provides a molecular option for the rapid, on-demand analysis of positive blood cultures. A preliminary evaluation of the iC-GPC assay using 203 clinical or seeded specimens demonstrated a sensitivity of 93.8% to 100% and a specificity of 98.0% to 100% for the identification of five Gram-positive bacterial species (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faecalis, and Enterococcus faecium) and three associated genetic resistance determinants (mecA, vanA, and vanB) in positive blood culture broths.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26468498      PMCID： PMC4652113          DOI： 10.1128/JCM.01934-15

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  17 in total

1.  Comparison of the MALDI Biotyper system using Sepsityper specimen processing to routine microbiological methods for identification of bacteria from positive blood culture bottles.

Authors:  Blake W Buchan; Katherine M Riebe; Nathan A Ledeboer
Journal:  J Clin Microbiol       Date:  2011-12-07       Impact factor: 5.948

2.  Impact of rapid in situ hybridization testing on coagulase-negative staphylococci positive blood cultures.

Authors:  Graeme N Forrest; Sanjay Mehta; Elizabeth Weekes; Durry P Lincalis; Jennifer K Johnson; Richard A Venezia
Journal:  J Antimicrob Chemother       Date:  2006-04-24       Impact factor: 5.790

3.  An antimicrobial stewardship program's impact with rapid polymerase chain reaction methicillin-resistant Staphylococcus aureus/S. aureus blood culture test in patients with S. aureus bacteremia.

Authors:  Karri A Bauer; Jessica E West; Joan-Miquel Balada-Llasat; Preeti Pancholi; Kurt B Stevenson; Debra A Goff
Journal:  Clin Infect Dis       Date:  2010-11-01       Impact factor: 9.079

4.  Early identification of microorganisms in blood culture prior to the detection of a positive signal in the BACTEC FX system using matrix-assisted laser desorption/ionization-time of flight mass spectrometry.

Authors:  Ming-Cheng Wang; Wei-Hung Lin; Jing-Jou Yan; Hsin-Yi Fang; Te-Hui Kuo; Chin-Chung Tseng; Jiunn-Jong Wu
Journal:  J Microbiol Immunol Infect       Date:  2013-12-30       Impact factor: 4.399

5.  Peptide nucleic acid fluorescent in situ hybridization for hospital-acquired enterococcal bacteremia: delivering earlier effective antimicrobial therapy.

Authors:  Graeme N Forrest; Mary-Claire Roghmann; Latoya S Toombs; Jennifer K Johnson; Elizabeth Weekes; Durry P Lincalis; Richard A Venezia
Journal:  Antimicrob Agents Chemother       Date:  2008-07-28       Impact factor: 5.191

6.  Rapid detection of Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) in wound specimens and blood cultures: multicenter preclinical evaluation of the Cepheid Xpert MRSA/SA skin and soft tissue and blood culture assays.

Authors:  D M Wolk; M J Struelens; P Pancholi; T Davis; P Della-Latta; D Fuller; E Picton; R Dickenson; O Denis; D Johnson; K Chapin
Journal:  J Clin Microbiol       Date:  2009-01-14       Impact factor: 5.948

7.  Integrating rapid pathogen identification and antimicrobial stewardship significantly decreases hospital costs.

Authors:  Katherine K Perez; Randall J Olsen; William L Musick; Patricia L Cernoch; James R Davis; Geoffrey A Land; Leif E Peterson; James M Musser
Journal:  Arch Pathol Lab Med       Date:  2012-12-06       Impact factor: 5.534

8.  Evaluation of a microarray-based assay for rapid identification of Gram-positive organisms and resistance markers in positive blood cultures.

Authors:  Linoj P Samuel; Robert J Tibbetts; Adam Agotesku; Margaret Fey; Rhonda Hensley; Frederick A Meier
Journal:  J Clin Microbiol       Date:  2013-01-30       Impact factor: 5.948

9.  Clinical validation of the molecular BD GeneOhm StaphSR assay for direct detection of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in positive blood cultures.

Authors:  Paul D Stamper; Mian Cai; Tracy Howard; Sharon Speser; Karen C Carroll
Journal:  J Clin Microbiol       Date:  2007-05-23       Impact factor: 5.948

10.  Multiplex identification of gram-positive bacteria and resistance determinants directly from positive blood culture broths: evaluation of an automated microarray-based nucleic acid test.

Authors:  Blake W Buchan; Christine C Ginocchio; Ryhana Manii; Robert Cavagnolo; Preeti Pancholi; Lettie Swyers; Richard B Thomson; Christopher Anderson; Karen Kaul; Nathan A Ledeboer
Journal:  PLoS Med       Date:  2013-07-02       Impact factor: 11.069
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  1 in total

Review 1.  Application of magnetic nanoparticles in nucleic acid detection.

Authors:  Congli Tang; Ziyu He; Hongmei Liu; Yuyue Xu; Hao Huang; Gaojian Yang; Ziqi Xiao; Song Li; Hongna Liu; Yan Deng; Zhu Chen; Hui Chen; Nongyue He
Journal:  J Nanobiotechnology       Date:  2020-04-21       Impact factor: 10.435
  1 in total

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