Literature DB >> 26467746

A monoclonal antibody specific for prophase phosphorylation of histone deacetylase 1: a readout for early mitotic cells.

Chiara V Segré1,2,3, Silvia Senese1,4,3, Sara Loponte1,3, Stefano Santaguida1,5, Paolo Soffientini1,6, Gabriela Grigorean1,7, Mario Cinquanta8, Giuseppe Ossolengo8, Christian Seiser9, Susanna Chiocca1.   

Abstract

Histone deacetylases (HDACs) are modification enzymes that regulate a plethora of biological processes. HDAC1, a crucial epigenetic modifier, is deregulated in cancer and subjected to a variety of post-translational modifications. Here, we describe the generation of a new monoclonal antibody that specifically recognizes a novel highly dynamic prophase phosphorylation of serine 406-HDAC1, providing a powerful tool for detecting early mitotic cells.

Entities:  

Keywords:  HDAC1; HDAC2; HDACs; antibody; cell cycle; checkpoint; mitosis; phosphorylation; post-translational modifications; prophase

Mesh：

Substances：

Year:  2015        PMID： 26467746      PMCID： PMC4966507          DOI： 10.1080/19420862.2015.1098795

Source DB:  PubMed          Journal:  MAbs        ISSN： 1942-0862            Impact factor:   5.857


  18 in total

1.  Mammalian histone deacetylase 1 protein is posttranslationally modified by phosphorylation.

Authors:  R Cai; P Kwon; Y Yan-Neale; L Sambuccetti; D Fischer; D Cohen
Journal:  Biochem Biophys Res Commun       Date:  2001-05-04       Impact factor: 3.575

Review 2.  HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention.

Authors:  X-J Yang; E Seto
Journal:  Oncogene       Date:  2007-08-13       Impact factor: 9.867

Review 3.  Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.

Authors:  P Todd Stukenberg; Daniel J Burke
Journal:  Chromosoma       Date:  2015-04-28       Impact factor: 4.316

4.  The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Authors:  Gordin Zupkovitz; Reinhard Grausenburger; Reinhard Brunmeir; Silvia Senese; Julia Tischler; Jennifer Jurkin; Martina Rembold; Dominique Meunier; Gerda Egger; Sabine Lagger; Susanna Chiocca; Fritz Propst; Georg Weitzer; Christian Seiser
Journal:  Mol Cell Biol       Date:  2009-12-22       Impact factor: 4.272

5.  Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase.

Authors:  I C Waizenegger; S Hauf; A Meinke; J M Peters
Journal:  Cell       Date:  2000-10-27       Impact factor: 41.582

6.  Histone deacetylase 1 phosphorylation promotes enzymatic activity and complex formation.

Authors:  M K Pflum; J K Tong; W S Lane; S L Schreiber
Journal:  J Biol Chem       Date:  2001-10-15       Impact factor: 5.157

7.  Highly selective enrichment of phosphorylated peptides using titanium dioxide.

Authors:  Tine E Thingholm; Thomas J D Jørgensen; Ole N Jensen; Martin R Larsen
Journal:  Nat Protoc       Date:  2006       Impact factor: 13.491

8.  Dynamic distribution of HDAC1 and HDAC2 during mitosis: association with F-actin.

Authors:  Shihua He; Dilshad H Khan; Stefan Winter; Christian Seiser; James R Davie
Journal:  J Cell Physiol       Date:  2013-07       Impact factor: 6.384

9.  Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression.

Authors:  Teppei Yamaguchi; Fabien Cubizolles; Yu Zhang; Nina Reichert; Hubertus Kohler; Christian Seiser; Patrick Matthias
Journal:  Genes Dev       Date:  2010-03-01       Impact factor: 11.361

10.  CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.

Authors:  S G Zeitlin; R D Shelby; K F Sullivan
Journal:  J Cell Biol       Date:  2001-12-24       Impact factor: 10.539
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  1 in total

1.  Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development.

Authors:  Sara Loponte; Chiara V Segré; Silvia Senese; Claudia Miccolo; Stefano Santaguida; Gianluca Deflorian; Simona Citro; Domenico Mattoscio; Federica Pisati; Mirjam A Moser; Rosella Visintin; Christian Seiser; Susanna Chiocca
Journal:  Sci Rep       Date:  2016-07-26       Impact factor: 4.379
  1 in total

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