PURPOSE: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). METHODS: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. RESULTS: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. CONCLUSION: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
PURPOSE: We analyzed overall survival (OS) following radioembolization according to macroscopic growth pattern (nodular vs infiltrative) and vascular invasion in intermediate-advanced hepatocellular carcinoma (HCC). METHODS: Between September 2005 and November 2013, 104 patients (50.0% portal vein thrombosis [PVT], 29.8% infiltrative morphology) were treated. RESULTS: Median OS differed significantly between patients with segmental and lobar or main PVT (p = 0.031), but was 17 months in both those with patent vessels and segmental PVT. Median OS did not differ for infiltrative and nodular HCC. Median OS was prolonged in patients with a treatment response at 3 months (p = 0.023). Prior TACE was also a significant predictor of improved OS. CONCLUSION: A further indication for radioembolization might be infiltrative HCC, since OS was similar to nodular types.
Authors: Mihir Gandhi; Su Pin Choo; Choon Hua Thng; Say Beng Tan; Albert Su Chong Low; Peng Chung Cheow; Anthony Soon Whatt Goh; Kiang Hiong Tay; Richard Hoau Gong Lo; Brian Kim Poh Goh; Jen San Wong; David Chee Eng Ng; Khee Chee Soo; Wei Ming Liew; Pierce K H Chow Journal: BMC Cancer Date: 2016-11-07 Impact factor: 4.430
Authors: Meaghan S Dendy; Juan C Camacho; Johannes M Ludwig; Alyssa M Krasinskas; Stuart J Knechtle; Hyun S Kim Journal: Transplant Direct Date: 2017-08-18