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Literature DB >> 2646639

tus, the trans-acting gene required for termination of DNA replication in Escherichia coli, encodes a DNA-binding protein.

T M Hill¹, M L Tecklenburg, A J Pelletier, P L Kuempel.

Abstract

The components for termination of DNA replication in Escherichia coli include the terminator signals T1 and T2 and the trans-acting gene tus. We have shown previously that tus maps in a 4-kilobase region of the chromosomal terminus near T2. Through the use of deletion and insertion mutants, the location of the tus gene has now been precisely identified. We sequenced 2416 nucleotides in this region and identified a 927-base-pair open reading frame which encodes Tus. Insertion of a kanamycin-resistance gene in this open reading frame abolished tus activity. We also demonstrated that crude extracts of tus+ cells contain a protein which binds to the T2 terminator sequence.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1989 PMID： 2646639 PMCID： PMC286744 DOI： 10.1073/pnas.86.5.1593

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. Potential metal-binding domains in nucleic acid binding proteins.

Authors: J M Berg
Journal: Science Date: 1986-04-25 Impact factor: 47.728

2. Sequence features of the replication terminus of the Bacillus subtilis chromosome.

Authors: C M Carrigan; J A Haarsma; M T Smith; R G Wake
Journal: Nucleic Acids Res Date: 1987-10-26 Impact factor: 16.971

3. Core sequence of two separable terminus sites of the R6K plasmid that exhibit polar inhibition of replication is a 20 bp inverted repeat.

Authors: T Horiuchi; M Hidaka
Journal: Cell Date: 1988-08-12 Impact factor: 41.582

4. DNA sequence requirements for replication fork arrest at terC in Bacillus subtilis.

Authors: M T Smith; R G Wake
Journal: J Bacteriol Date: 1988-09 Impact factor: 3.490

5. Termination of DNA replication in Escherichia coli requires a trans-acting factor.

Authors: T M Hill; B J Kopp; P L Kuempel
Journal: J Bacteriol Date: 1988-02 Impact factor: 3.490

6. A dimer of AraC protein contacts three adjacent major groove regions of the araI DNA site.

Authors: W Hendrickson; R Schleif
Journal: Proc Natl Acad Sci U S A Date: 1985-05 Impact factor: 11.205

7. Inhibition of replication forks exiting the terminus region of the Escherichia coli chromosome occurs at two loci separated by 5 min.

Authors: B de Massy; S Béjar; J Louarn; J M Louarn; J P Bouché
Journal: Proc Natl Acad Sci U S A Date: 1987-04 Impact factor: 11.205

8. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.

Authors: W H Landschulz; P F Johnson; S L McKnight
Journal: Science Date: 1988-06-24 Impact factor: 47.728

9. Location of sites that inhibit progression of replication forks in the terminus region of Escherichia coli.

Authors: A J Pelletier; T M Hill; P L Kuempel
Journal: J Bacteriol Date: 1988-09 Impact factor: 3.490

10. Induction of nitrogen-fixing nodules on clover requires only 32 kilobase pairs of DNA from the Rhizobium trifolii symbiosis plasmid.

Authors: R W Innes; M A Hirose; P L Kuempel
Journal: J Bacteriol Date: 1988-09 Impact factor: 3.490

42 in total

1. Replication terminator protein of Escherichia coli is a transcriptional repressor of its own synthesis.

Authors: S Natarajan; W L Kelley; D Bastia
Journal: Proc Natl Acad Sci U S A Date: 1991-05-01 Impact factor: 11.205

Review 2. Replication termination in Escherichia coli: structure and antihelicase activity of the Tus-Ter complex.

Authors: Cameron Neylon; Andrew V Kralicek; Thomas M Hill; Nicholas E Dixon
Journal: Microbiol Mol Biol Rev Date: 2005-09 Impact factor: 11.056

Review 3. Replication fork stalling at natural impediments.

Authors: Ekaterina V Mirkin; Sergei M Mirkin
Journal: Microbiol Mol Biol Rev Date: 2007-03 Impact factor: 11.056

4. A newly identified DNA replication terminus site, TerE, on the Escherichia coli chromosome.

Authors: M Hidaka; T Kobayashi; T Horiuchi
Journal: J Bacteriol Date: 1991-01 Impact factor: 3.490

5. The progression of replication forks at natural replication barriers in live bacteria.

Authors: M Charl Moolman; Sriram Tiruvadi Krishnan; Jacob W J Kerssemakers; Roy de Leeuw; Vincent Lorent; David J Sherratt; Nynke H Dekker
Journal: Nucleic Acids Res Date: 2016-05-10 Impact factor: 16.971

6. Escherichia coli replication termination protein impedes the action of helicases.

Authors: E H Lee; A Kornberg; M Hidaka; T Kobayashi; T Horiuchi
Journal: Proc Natl Acad Sci U S A Date: 1989-12 Impact factor: 11.205

Review 7. Mechanism and physiological significance of programmed replication termination.

Authors: Deepak Bastia; Shamsu Zaman
Journal: Semin Cell Dev Biol Date: 2014-05-06 Impact factor: 7.727

8. CD and DNA binding studies of a proline repeat-containing segment of the replication arrest protein Tus.

Authors: M L Nedved; P A Gottlieb; G R Moe
Journal: Nucleic Acids Res Date: 1994-11-25 Impact factor: 16.971

9. Escherichia coli replication terminator protein impedes simian virus 40 (SV40) DNA replication fork movement and SV40 large tumor antigen helicase activity in vitro at a prokaryotic terminus sequence.

Authors: C L Bedrosian; D Bastia
Journal: Proc Natl Acad Sci U S A Date: 1991-04-01 Impact factor: 11.205

10. In silico 'fishing' using known small regulatory RNA (sRNA) candidates as the decoy from Escherichia coli, Salmonella typhi and Salmonella typhimurium manifested 14 novel sRNA candidates in the orthologous region of Proteus mirabilis.

Authors: Selvaraju KishanRaj; Samuggam Sumitha; Balakrishnan Siventhiran; Othayakumar Thiviyaa; Kathiresan V Sathasivam; Rathinam Xavier; Thean-Hock Tang; Marimuthu Citartan; Suresh V Chinni
Journal: Mol Biol Rep Date: 2018-10-03 Impact factor: 2.316