OBJECTIVE: The objective was to determine the effects of the probiotic, VSL#3, on body and fat mass, insulin sensitivity, and skeletal muscle substrate oxidation following 4 weeks of a high-fat diet. METHODS:Twenty non-obese males (18-30 years) participated in the study. Following a 2-week eucaloric control diet, participants underwent dual X-ray absorptiometry to determine body composition, an intravenous glucose tolerance test to determine insulin sensitivity, and a skeletal muscle biopsy for measurement of in vitro substrate oxidation. Subsequently, participants were randomized to receive either VSL#3 or placebo daily during 4 weeks of consuming a High-fat (55% fat), hypercaloric diet (+1,000kcal day(-1) ). Participants repeated all measurements following the intervention. RESULTS:Body mass (1.42 ± 0.42 kg vs. 2.30 ± 0.28 kg) and fat mass (0.63 ± 0.09 kg vs. 1.29 ± 0.27 kg) increased less following the High-fat diet in the VSL#3 group compared with placebo. However, there were no significant changes in insulin sensitivity or in vitro skeletal muscle pyruvate and fat oxidation with the High-fat diet or VSL#3. CONCLUSIONS:VSL#3 supplementation appears to have provided some protection from body mass gain and fat accumulation in healthy young men consuming a High-fat and high-energy diet.
RCT Entities:
OBJECTIVE: The objective was to determine the effects of the probiotic, VSL#3, on body and fat mass, insulin sensitivity, and skeletal muscle substrate oxidation following 4 weeks of a high-fat diet. METHODS: Twenty non-obese males (18-30 years) participated in the study. Following a 2-week eucaloric control diet, participants underwent dual X-ray absorptiometry to determine body composition, an intravenous glucose tolerance test to determine insulin sensitivity, and a skeletal muscle biopsy for measurement of in vitro substrate oxidation. Subsequently, participants were randomized to receive either VSL#3 or placebo daily during 4 weeks of consuming a High-fat (55% fat), hypercaloric diet (+1,000 kcal day(-1) ). Participants repeated all measurements following the intervention. RESULTS: Body mass (1.42 ± 0.42 kg vs. 2.30 ± 0.28 kg) and fat mass (0.63 ± 0.09 kg vs. 1.29 ± 0.27 kg) increased less following the High-fat diet in the VSL#3 group compared with placebo. However, there were no significant changes in insulin sensitivity or in vitro skeletal muscle pyruvate and fat oxidation with the High-fat diet or VSL#3. CONCLUSIONS: VSL#3 supplementation appears to have provided some protection from body mass gain and fat accumulation in healthy young men consuming a High-fat and high-energy diet.
Authors: Rodrigo San-Cristobal; Santiago Navas-Carretero; Miguel Ángel Martínez-González; José María Ordovas; José Alfredo Martínez Journal: Nat Rev Endocrinol Date: 2020-03-31 Impact factor: 43.330
Authors: Nancy A Mervish; Jianzhong Hu; Loy A Hagan; Manish Arora; Catalina Frau; Julee Choi; Ali Attaie; Mairaj Ahmed; Susan L Teitelbaum; Mary S Wolff Journal: J Child Obes Date: 2019-03-13
Authors: Lotta K Stenman; Markus J Lehtinen; Nils Meland; Jeffrey E Christensen; Nicolas Yeung; Markku T Saarinen; Michael Courtney; Rémy Burcelin; Marja-Leena Lähdeaho; Jüri Linros; Dan Apter; Mika Scheinin; Hilde Kloster Smerud; Aila Rissanen; Sampo Lahtinen Journal: EBioMedicine Date: 2016-10-26 Impact factor: 8.143