OBJECTIVE: The aim of this study was to evaluate distribution and clinical significance of high signal intensity of the myocardium on T2-weighted images (T2-HI) in 2 phenotypes of hypertrophic cardiomyopathy (HCM). METHODS: Thirty-six patients with asymmetrical septal HCM (ASH) and 18 patients with apical HCM (APH) and their 864 myocardial segments were investigated. The distribution of T2-HI was compared with that of late gadolinium enhancement (LGE), and the relationships between T2-HI and clinical risk markers were evaluated. T2 values of the T2-HI were estimated with T2 mapping. RESULTS: The T2-HI was observed in 18 segments (3.1%) in 13 patients with ASH (36.1%) and in 12 segments (4.2%) in 8 patients with APH (44.4%). It was often localized outside LGE. The presence of T2-HI was related to syncope in ASH (P = 0.016). Furthermore, it had higher T2 values (61.1 milliseconds) than the reference myocardium (47.3 milliseconds). CONCLUSIONS: High signal intensity of the myocardium on T2-weighted images often locates outside LGE and reflects myocardial damage, which is related to syncope in ASH.
OBJECTIVE: The aim of this study was to evaluate distribution and clinical significance of high signal intensity of the myocardium on T2-weighted images (T2-HI) in 2 phenotypes of hypertrophic cardiomyopathy (HCM). METHODS: Thirty-six patients with asymmetrical septal HCM (ASH) and 18 patients with apical HCM (APH) and their 864 myocardial segments were investigated. The distribution of T2-HI was compared with that of late gadolinium enhancement (LGE), and the relationships between T2-HI and clinical risk markers were evaluated. T2 values of the T2-HI were estimated with T2 mapping. RESULTS: The T2-HI was observed in 18 segments (3.1%) in 13 patients with ASH (36.1%) and in 12 segments (4.2%) in 8 patients with APH (44.4%). It was often localized outside LGE. The presence of T2-HI was related to syncope in ASH (P = 0.016). Furthermore, it had higher T2 values (61.1 milliseconds) than the reference myocardium (47.3 milliseconds). CONCLUSIONS: High signal intensity of the myocardium on T2-weighted images often locates outside LGE and reflects myocardial damage, which is related to syncope in ASH.
Authors: D H Frank Gommans; G Etienne Cramer; Jeannette Bakker; Hendrik-Jan Dieker; Michelle Michels; Michael A Fouraux; Carlo L M Marcelis; Freek W A Verheugt; Janneke Timmermans; Marc A Brouwer; Marcel J M Kofflard Journal: Int J Cardiovasc Imaging Date: 2017-10-23 Impact factor: 2.357
Authors: G Etienne Cramer; D H Frank Gommans; Hendrik-Jan Dieker; Michelle Michels; Freek Verheugt; Menko-Jan de Boer; Jeannette Bakker; Michael A Fouraux; Janneke Timmermans; Marcel Kofflard; Marc Brouwer Journal: Heart Date: 2020-01-30 Impact factor: 5.994
Authors: Elizabeth W Thompson; Srikant Kamesh Iyer; Michael P Solomon; Zhaohuan Li; Qiang Zhang; Stefan Piechnik; Konrad Werys; Sophia Swago; Brianna F Moon; Zachary B Rodgers; Anya Hall; Rishabh Kumar; Nosheen Reza; Jessica Kim; Alisha Jamil; Benoit Desjardins; Harold Litt; Anjali Owens; Walter R T Witschey; Yuchi Han Journal: J Cardiovasc Magn Reson Date: 2021-10-25 Impact factor: 5.364
Authors: Francisco Vasques-Nóvoa; António Angélico-Gonçalves; José M G Alvarenga; João Nobrega; Rui J Cerqueira; Jennifer Mancio; Adelino F Leite-Moreira; Roberto Roncon-Albuquerque Journal: ESC Heart Fail Date: 2022-02-11