| Literature DB >> 26465655 |
Olivia Schimming1, Victoria L Challinor1, Nicholas J Tobias1, Hélène Adihou1, Peter Grün1, Laura Pöschel1, Christian Richter2, Harald Schwalbe2, Helge B Bode3,4.
Abstract
Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.Entities:
Keywords: Baeyer-Villiger oxidation; biosynthesis; natural products; non-ribosomal peptide synthetases; pyrrolizidine alkaloids
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Year: 2015 PMID： 26465655 DOI： 10.1002/anie.201504877
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336