Fan Zeng1, Kui Liao2, Jiayan Wu1, Yue Gao1, Haiyu Li1, Jianjun Fan1, Hantao Zhang1, Yun Li1, Xin Bai1, Geili Liu1, Fangzhou Song3. 1. Molecular Medicine & Cancer Research Center, College of Basic Medicine, Chongqing Medical University Chongqing, China. 2. Department of Oncology, The First Affiliated Hospital of Chongqing Medical University Chongqing 400016, China. 3. Molecular Medicine & Cancer Research Center, College of Basic Medicine, Chongqing Medical University Chongqing, China ; Department of Biochemistry & Molecular Biology, College of Basic Medicine, Chongqing Medical University Chongqing, China.
Abstract
UNLABELLED: The armadillo repeat proteins were first found in armadillo gene of Drosophila. Since then a number of proteins containing armadillo repeats have been noticed and studied. These proteins that consist of 6 to 13 armadillo repeat domains are classified as family of armadillo repeat proteins. Recently, several studies indicated that armadillo repeat family of proteins play an important role in the tumorigenesis and maintenance of tissue integrity. ALEX1 (Arm protein lost in epithelial cancers, on chromosome X), contains two armadillo repeats domains, is expressed different in normal and carcinomas tissues. Several studies have found that ALEX1 protein lost in tumors that originated in epithelial tissues. We evaluated the ALEX1 protein expression in 53 cervical cancers and in 53 non-cancerous cervical tissues from patients and adjacent non-cancerous tissues using immunohistochemistry RESULTS: ALEX1 protein expression is significantly increased in 53 cervical cancers tissues compared with non-cancerous tissues. We found, for the first time, that ALEX1 protein expression in cervical cancers tissues is higher than non-cancerous tissues. It is suggested that the ALEX1 protein is associated with tumorigenesis in cervical cancer and we speculate that the ALEX1 may plays a role as an oncogene in cervical cancer. Moreover, ALEX1 may serve as a novel potential diagnostic biomarker in identifying cervical cancer.
UNLABELLED: The armadillo repeat proteins were first found in armadillo gene of Drosophila. Since then a number of proteins containing armadillo repeats have been noticed and studied. These proteins that consist of 6 to 13 armadillo repeat domains are classified as family of armadillo repeat proteins. Recently, several studies indicated that armadillo repeat family of proteins play an important role in the tumorigenesis and maintenance of tissue integrity. ALEX1 (Arm protein lost in epithelial cancers, on chromosome X), contains two armadillo repeats domains, is expressed different in normal and carcinomas tissues. Several studies have found that ALEX1 protein lost in tumors that originated in epithelial tissues. We evaluated the ALEX1 protein expression in 53 cervical cancers and in 53 non-cancerous cervical tissues from patients and adjacent non-cancerous tissues using immunohistochemistry RESULTS:ALEX1 protein expression is significantly increased in 53 cervical cancers tissues compared with non-cancerous tissues. We found, for the first time, that ALEX1 protein expression in cervical cancers tissues is higher than non-cancerous tissues. It is suggested that the ALEX1 protein is associated with tumorigenesis in cervical cancer and we speculate that the ALEX1 may plays a role as an oncogene in cervical cancer. Moreover, ALEX1 may serve as a novel potential diagnostic biomarker in identifying cervical cancer.
Authors: Ji Zhang; Xiao-Bin Wu; Jian-Jun Fan; Li Mai; Wei Cai; Dan Li; Cheng-Fu Yuan; You-Quan Bu; Fang-Zhou Song Journal: Asian Pac J Cancer Prev Date: 2013
Authors: Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John M Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe Journal: Cell Date: 2008-11-13 Impact factor: 41.582