Israt Hafiz1, Patricia Graves2, Rouseli Haq3, Meerjady Sabrina Flora4, Louise A Kelly-Hope5. 1. Filarial Programmes Support Unit-Liverpool School of Tropical Medicine, Liverpool, UK. 2. Australian Institute of Tropical Health and Medicine and College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Australia. 3. Filariasis Elimination Program, Directorate General of Health Services, Dhaka, Bangladesh. 4. National Institute of Preventive and Social Medicine, Dhaka, Bangladesh. 5. Filarial Programmes Support Unit-Liverpool School of Tropical Medicine, Liverpool, UK Australian Institute of Tropical Health and Medicine and College of Public Health, Medical and Veterinary Sciences, James Cook University, Cairns, Australia Louise.Kelly-Hope@lstmed.ac.uk.
Abstract
BACKGROUND: Bangladesh has a high burden of lymphatic filariasis (LF) disease. This survey estimated the current number of clinical cases in a historically endemic district after a decade of mass drug administration (MDA). METHODS: A cluster survey was conducted in 30 villages of Nilphamari District. Ten households per village were randomly selected, and individuals with LF clinical conditions identified. Hydrocoele and lymphoedema (leg, arm, breast) cases were quantified and mapped, and differences by sex, age, severity of disease and episodes of acute dermatolymphangioadenitis attacks (ADLA) examined. RESULTS: From 1242 surveyed >10 years old 55 individuals (4.4%) with LF clinical conditions were identified. Males were mostly affected by hydrocoeles, and females by leg lymphoedema. Higher prevalence and more advanced stages of disease were found in older age groups. CONCLUSIONS: Overall low prevalence of severe clinical disease was found, which has positive implications for the elimination goal. Future planning of MMDP strategies will need to address the varying clinical conditions, severity of disease and impact of ADLAs affecting different sub-groups of the population. It will also be important to monitor for new cases, and examine the shift in age distribution of cases over time.
BACKGROUND: Bangladesh has a high burden of lymphatic filariasis (LF) disease. This survey estimated the current number of clinical cases in a historically endemic district after a decade of mass drug administration (MDA). METHODS: A cluster survey was conducted in 30 villages of Nilphamari District. Ten households per village were randomly selected, and individuals with LF clinical conditions identified. Hydrocoele and lymphoedema (leg, arm, breast) cases were quantified and mapped, and differences by sex, age, severity of disease and episodes of acute dermatolymphangioadenitis attacks (ADLA) examined. RESULTS: From 1242 surveyed >10 years old 55 individuals (4.4%) with LF clinical conditions were identified. Males were mostly affected by hydrocoeles, and females by leg lymphoedema. Higher prevalence and more advanced stages of disease were found in older age groups. CONCLUSIONS: Overall low prevalence of severe clinical disease was found, which has positive implications for the elimination goal. Future planning of MMDP strategies will need to address the varying clinical conditions, severity of disease and impact of ADLAs affecting different sub-groups of the population. It will also be important to monitor for new cases, and examine the shift in age distribution of cases over time.
Authors: A K M Shamsuzzaman; Rouseli Haq; Mohammad J Karim; Motasim B Azad; A S M Sultan Mahmood; Abul Khair; Muhammad Mujibur Rahman; Israt Hafiz; K D Ramaiah; Charles D Mackenzie; Hayley E Mableson; Louise A Kelly-Hope Journal: PLoS Negl Trop Dis Date: 2017-01-31
Authors: Mohammad J Karim; Rouseli Haq; Hayley E Mableson; A S M Sultan Mahmood; Mujibur Rahman; Salim M Chowdhury; A K M Fazlur Rahman; Israt Hafiz; Hannah Betts; Charles Mackenzie; Mark J Taylor; Louise A Kelly-Hope Journal: PLoS Negl Trop Dis Date: 2019-07-15
Authors: Hugh Shirley; Grace Grifferty; Elizabeth F Yates; Nakul Raykar; Richard Wamai; Craig D McClain Journal: Ann Glob Health Date: 2022-08-08 Impact factor: 3.640