| Literature DB >> 26464086 |
Jurgen R Haanstra1, Barbara M Bakker2.
Abstract
To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.Entities:
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Year: 2015 PMID： 26464086 DOI： 10.1016/j.ddtec.2015.06.002
Source DB: PubMed Journal: Drug Discov Today Technol ISSN： 1740-6749